Rol' kholesterina v aktivatsii perekisnogo okiseniia lipidov v trombotsitakh.

Translated title of the contribution: The role of cholesterol in activating lipid peroxidation in platelets

V. S. Gurevich, L. V. Shatilina, I. G. Kovaleva, B. G. Bershadskiǐ

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The relationship between the cholesterol (Ch) content and the concentration of lipid peroxidation (LPO) products in activated platelets and the effect of these parameters on the structure-function characteristics of platelet membranes were studied. It was found that esterified Ch activates free radical processes occurring in platelets. Nonesterified Ch does not induce the production of primary products of LPO (dienoic conjugates) but promotes the accumulation of a secondary LPO metabolite, malonic dialdehyde, this reaction being mediated via indirect mechanisms. The higher (in comparison with normal) orderliness and orientation of membranes in platelets reflect the increase in the concentration of dienoic conjugates and nonesterified Ch. The observed differences in the aggregability of platelets are due to the changes in the Ch content as well as to the "rigidity" of blood platelets.

Translated title of the contributionThe role of cholesterol in activating lipid peroxidation in platelets
Original languageRussian
Pages (from-to)267-274
Number of pages8
JournalBiokhimiya
Volume57
Issue number2
StatePublished - 1 Feb 1992

Scopus subject areas

  • Chemistry(all)

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