RhII-Catalyzed Cycloaddition of α-Diazo Homophthalimides and Nitriles Delivers Oxazolo[5,4-c]isoquinolin-5(4H)-one Scaffold

    Research output

    6 Citations (Scopus)

    Abstract

    Homophthalimides underwent facile diazo transfer reactions and the resulting diazo homophthalimides entered cycloaddition reactions with nitriles catalyzed by Rh2(OAc)4. The latter reaction represents the first example of 1,3-oxazole synthesis involving nitrile cycloaddition to an α-diazocarbonyl moiety incorporated in a heterocyclic system. The resulting oxazolo[5,4-c]isoquinolin-5(4H)-one scaffold represents a hitherto not described structural analog of an important cluster of tricyclic ring systems for drug design.

    Original languageEnglish
    Pages (from-to)4857-4859
    Number of pages3
    JournalEuropean Journal of Organic Chemistry
    Volume2018
    Issue number35
    DOIs
    Publication statusPublished - 23 Sep 2018

    Scopus subject areas

    • Physical and Theoretical Chemistry
    • Organic Chemistry

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