Results of treatment of locally recurring soft tissues sarcomas of extremities

G. V. Zinoviev, G. I. Gafton, I. G. Gafton, E. A. Busko, I. A. Grinenko, A. B. Elmurzaev, R. A. Kadyrleev

Research output

Abstract

Background: The most striking clinical feature of soft tissues sarcomas (STS) is their ability to recur. At present disputes about the clinical and morphological factors of STS recurrence such as the degree of malignancy, size, location, depth of tumor location, patient's age and the presence of previous relapses in the anamnesis do not subside. It also requires clarification of the effect of the volume of tissues removed on the long-term results of treatment of STS as well as indications for the application of various regimes of remote radiation therapy. Materials and methods: Of 1802 registered cases of STS of extremities at the N.N. Petrov National Medical Research Center of Oncology from 2004 to 2016 there were selected data on 213 patients who suffered from at least one relapse of the disease. There was performed an assessment of overall, non-metastatic and disease-free survival using a single-factor (the Kaplan-Meier method) and multivariate analysis (the Cox regression model). Conclusion: The detection of various prognostic factors of locally recurrent STS allows determining the necessary treatment tactics (the vastness and traumatism of surgery and the advisability of radiation therapy).

Original languageEnglish
Pages (from-to)408-413
Number of pages6
JournalVoprosy Onkologii
Volume64
Issue number3
Publication statusPublished - 1 Jan 2018

Fingerprint

Sarcoma
Extremities
Recurrence
Radiotherapy
Therapeutics
Aptitude
Dissent and Disputes
Kaplan-Meier Estimate
Proportional Hazards Models
Disease-Free Survival
Biomedical Research
Neoplasms
Multivariate Analysis

Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Zinoviev, G. V., Gafton, G. I., Gafton, I. G., Busko, E. A., Grinenko, I. A., Elmurzaev, A. B., & Kadyrleev, R. A. (2018). Results of treatment of locally recurring soft tissues sarcomas of extremities. Voprosy Onkologii, 64(3), 408-413.
Zinoviev, G. V. ; Gafton, G. I. ; Gafton, I. G. ; Busko, E. A. ; Grinenko, I. A. ; Elmurzaev, A. B. ; Kadyrleev, R. A. / Results of treatment of locally recurring soft tissues sarcomas of extremities. In: Voprosy Onkologii. 2018 ; Vol. 64, No. 3. pp. 408-413.
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abstract = "Background: The most striking clinical feature of soft tissues sarcomas (STS) is their ability to recur. At present disputes about the clinical and morphological factors of STS recurrence such as the degree of malignancy, size, location, depth of tumor location, patient's age and the presence of previous relapses in the anamnesis do not subside. It also requires clarification of the effect of the volume of tissues removed on the long-term results of treatment of STS as well as indications for the application of various regimes of remote radiation therapy. Materials and methods: Of 1802 registered cases of STS of extremities at the N.N. Petrov National Medical Research Center of Oncology from 2004 to 2016 there were selected data on 213 patients who suffered from at least one relapse of the disease. There was performed an assessment of overall, non-metastatic and disease-free survival using a single-factor (the Kaplan-Meier method) and multivariate analysis (the Cox regression model). Conclusion: The detection of various prognostic factors of locally recurrent STS allows determining the necessary treatment tactics (the vastness and traumatism of surgery and the advisability of radiation therapy).",
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Zinoviev, GV, Gafton, GI, Gafton, IG, Busko, EA, Grinenko, IA, Elmurzaev, AB & Kadyrleev, RA 2018, 'Results of treatment of locally recurring soft tissues sarcomas of extremities', Voprosy Onkologii, vol. 64, no. 3, pp. 408-413.

Results of treatment of locally recurring soft tissues sarcomas of extremities. / Zinoviev, G. V.; Gafton, G. I.; Gafton, I. G.; Busko, E. A.; Grinenko, I. A.; Elmurzaev, A. B.; Kadyrleev, R. A.

In: Voprosy Onkologii, Vol. 64, No. 3, 01.01.2018, p. 408-413.

Research output

TY - JOUR

T1 - Results of treatment of locally recurring soft tissues sarcomas of extremities

AU - Zinoviev, G. V.

AU - Gafton, G. I.

AU - Gafton, I. G.

AU - Busko, E. A.

AU - Grinenko, I. A.

AU - Elmurzaev, A. B.

AU - Kadyrleev, R. A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The most striking clinical feature of soft tissues sarcomas (STS) is their ability to recur. At present disputes about the clinical and morphological factors of STS recurrence such as the degree of malignancy, size, location, depth of tumor location, patient's age and the presence of previous relapses in the anamnesis do not subside. It also requires clarification of the effect of the volume of tissues removed on the long-term results of treatment of STS as well as indications for the application of various regimes of remote radiation therapy. Materials and methods: Of 1802 registered cases of STS of extremities at the N.N. Petrov National Medical Research Center of Oncology from 2004 to 2016 there were selected data on 213 patients who suffered from at least one relapse of the disease. There was performed an assessment of overall, non-metastatic and disease-free survival using a single-factor (the Kaplan-Meier method) and multivariate analysis (the Cox regression model). Conclusion: The detection of various prognostic factors of locally recurrent STS allows determining the necessary treatment tactics (the vastness and traumatism of surgery and the advisability of radiation therapy).

AB - Background: The most striking clinical feature of soft tissues sarcomas (STS) is their ability to recur. At present disputes about the clinical and morphological factors of STS recurrence such as the degree of malignancy, size, location, depth of tumor location, patient's age and the presence of previous relapses in the anamnesis do not subside. It also requires clarification of the effect of the volume of tissues removed on the long-term results of treatment of STS as well as indications for the application of various regimes of remote radiation therapy. Materials and methods: Of 1802 registered cases of STS of extremities at the N.N. Petrov National Medical Research Center of Oncology from 2004 to 2016 there were selected data on 213 patients who suffered from at least one relapse of the disease. There was performed an assessment of overall, non-metastatic and disease-free survival using a single-factor (the Kaplan-Meier method) and multivariate analysis (the Cox regression model). Conclusion: The detection of various prognostic factors of locally recurrent STS allows determining the necessary treatment tactics (the vastness and traumatism of surgery and the advisability of radiation therapy).

KW - Prognostic factors

KW - Radiation therapy for sarcoma

KW - Recurrence factors

KW - Sarcoma recurrence

KW - Soft tissue sarcomas

KW - Surgical treatment for sarcoma

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JO - Voprosy Onkologii

JF - Voprosy Onkologii

SN - 0507-3758

IS - 3

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Zinoviev GV, Gafton GI, Gafton IG, Busko EA, Grinenko IA, Elmurzaev AB et al. Results of treatment of locally recurring soft tissues sarcomas of extremities. Voprosy Onkologii. 2018 Jan 1;64(3):408-413.