Regulatory mechanisms for apoptosis in placental tissue during normal pregnancy and gestosis-complicated pregnancy

D. I. Sokolov, A. V. Kolobov, M. V. Lesnichija, I. N. Kostiouchek, O. I. Stepanova, I. M. Kvetnoy, S. A. Selkov

Research output

10 Citations (Scopus)

Abstract

The localization of apoptosis and expression of proapoptotic and antiapoptotic factors by the placental tissue were compared during normal pregnancy and gestosis-complicated pregnancy. The degree of apoptosis did not differ in the third trimester of normal pregnancy and gestosis-complicated pregnancy. Increased expression of Fas, caspase-8, and caspase-3 in placental tissue during normal pregnancy was shown to contribute to the suppression of angiogenesis and growth of placental tissue. No differences were found in the expression of FasL (CD95L), caspase-2, caspase-9, and Mcl-1 by placental cells during normal pregnancy and gestosis-complicated pregnancy. Increased expression of TRAIL by trophoblast cells is a protective mechanism from apoptotic signals of maternal cytotoxic lymphocytes and NK cells during gestosis.

Original languageEnglish
Pages (from-to)766-770
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume148
Issue number5
DOIs
Publication statusPublished - 1 Nov 2009

Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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