Regulation of antimicrobial peptide synthesis in larvae of Calliphora vicina (Diptera, Calliphoridae): a dose-dependent effect of ecdysteroids

N. A. Gordya, A. P. Nesin, N. P. Simonenko, S. I. Chernysh

Research output

Abstract

Ecdysteroids are multifunctional hormones regulating virtually all morphogenetic events in insects. Their role in stress and immune response regulation is not well researched. Here we study the effect of 20-hydroxyecdysone on antimicrobial peptide synthesis in the larvae of Calliphora vicina. An inverse correlation was observed between the 20-hydroxyecdysone titer and antimicrobial peptide concentration in the hemolymph of naïve and bacteria challenged maggots. High and low doses of 20-hydroxyecdysone, injected simultaneously with bacterial cells, had an opposite effect on antimicrobial peptide synthesis in the diapausing larvae. Morphogenetically effective doses of 20-hydroxyecdysone demonstrated immunosuppressive activity. A low dose of 20-hydroxyecdysone, on the contrary, moderately stimulated antimicrobial peptide synthesis. The data suggest that ecdysteroids are directly involved in the regulation of the immune system activity and that the final effect is dose-dependant.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalJournal of Evolutionary Biochemistry and Physiology
Volume52
Issue number4
DOIs
Publication statusPublished - 1 Jul 2016

Scopus subject areas

  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry

Fingerprint Dive into the research topics of 'Regulation of antimicrobial peptide synthesis in larvae of Calliphora vicina (Diptera, Calliphoridae): a dose-dependent effect of ecdysteroids'. Together they form a unique fingerprint.

  • Cite this