QUANTUM NATURE OF THE CODON-ANTICODON INTERACTION

Alexander A Tulub

Research output

Abstract

Despite impressive progress in molecular biology and genetics over the last decades, the key question is still unanswered—why the genetic code is triplet and what information it keeps and transfers over translation. Unexpectedly, the answer comes not from biology but from spin physics and computational quantum chemistry. The study aims to shed light on howmRNAsees the right tRNA and what sort of communication ensures the codon–anticodon recognition. The data rests on the quantum mechanical/molecular mechanical quantum chemistry computations of the mRNA-tRNA fragments differing in 61 codon–anticodon nucleotide triplets coding 20 canonical amino acids.
Original languageEnglish
Article number025001
Pages (from-to)025001
Number of pages6
JournalBiomedical Physics & Engineering Express
Volume4
Issue number2
DOIs
Publication statusPublished - 1 Mar 2018

Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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