Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases

Andrey Trulioff, Alexander Ermakov, Yegor Malashichev

Research output: Contribution to journalLiterature review

24 Scopus citations

Abstract

Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry.
Original languageEnglish
Pages (from-to)48
JournalGenes
Volume8
Issue number2
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • schizophrenia
  • centrosome
  • left-right asymmetry
  • Disc1
  • PCM-1
  • pericentrin
  • abelson helper integrator 1
  • hamartin
  • DCDC2
  • Dyx1c1

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