The paper is devoted to the development of the Altai Territory (the Russian Federation) as a border region with the involvement of production potential and capabilities of the neighboring region – East Kazakhstan Region (the Republic of Kazakhstan). The authors performed a SWOT analysis of the regions as a "cross-border growth pole". The study also examines the development of a border region in the context of the theory of integration and clustering. The authors suggest an algorithm for creating a local development axis in the territory of a border region. Agricultural engineering is presented as the main branch of cooperation between the Altai Territory and the East Kazakhstan Region. Moreover, the paper examines the form of enterprise management within the local development axis and the effect of these enterprises functioning.