Orcinol Glucoside Loaded Polymer - Lipid Hybrid Nanostructured Lipid Carriers: Potential Cytotoxic Agents against Gastric, Colon and Hepatoma Carcinoma Cell Lines

Prasant Nahak, Rahul L. Gajbhiye, Gourab Karmakar, Pritam Guha, Biplab Roy, Shila Elizabeth Besra, Алексей Геннадьевич Быков, Александр Владимирович Акентьев, Борис Анатольевич Носков, Kaushik Nag, Parasuraman Jaisankar, Amiya Kumar Panda

Research output

3 Citations (Scopus)

Abstract

Orcinol glucoside (OG) - loaded nanostructured lipid carrier (NLC), coated with polyethylene glycol-25/55-stearate (PEG-25/55-SA), were explored for delivering OG to improve in vitro cytotoxicity against gastrointestinal tract (GIT), colon and hepatoma carcinoma cell lines. It is being expected that the PEGylated formulations would possess the sustainability in withstanding the adverse physiological extremities like the most significant metabolic activities and phase I / II enzymatic activities in the intestines.
Original languageEnglish
Article number198
Pages (from-to)1-10
Number of pages10
JournalPharmaceutical Research
Volume35
Issue number10
Publication statusPublished - Oct 2018

Fingerprint

Cytotoxins
Glucosides
Hepatocellular Carcinoma
Stomach
Polymers
Colon
Cells
Carcinoma
Lipids
Cell Line
Cytotoxicity
Intestines
Gastrointestinal Tract
Sustainable development
Extremities
orcinol
polyethylene glycol monostearate
In Vitro Techniques

Scopus subject areas

  • Chemistry(all)

Cite this

Nahak, P., Gajbhiye, R. L., Karmakar, G., Guha, P., Roy, B., Besra, S. E., ... Panda, A. K. (2018). Orcinol Glucoside Loaded Polymer - Lipid Hybrid Nanostructured Lipid Carriers: Potential Cytotoxic Agents against Gastric, Colon and Hepatoma Carcinoma Cell Lines. Pharmaceutical Research, 35(10), 1-10. [198].
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abstract = "Orcinol glucoside (OG) - loaded nanostructured lipid carrier (NLC), coated with polyethylene glycol-25/55-stearate (PEG-25/55-SA), were explored for delivering OG to improve in vitro cytotoxicity against gastrointestinal tract (GIT), colon and hepatoma carcinoma cell lines. It is being expected that the PEGylated formulations would possess the sustainability in withstanding the adverse physiological extremities like the most significant metabolic activities and phase I / II enzymatic activities in the intestines.",
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author = "Prasant Nahak and Gajbhiye, {Rahul L.} and Gourab Karmakar and Pritam Guha and Biplab Roy and Besra, {Shila Elizabeth} and Быков, {Алексей Геннадьевич} and Акентьев, {Александр Владимирович} and Носков, {Борис Анатольевич} and Kaushik Nag and Parasuraman Jaisankar and Panda, {Amiya Kumar}",
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AU - Nahak, Prasant

AU - Gajbhiye, Rahul L.

AU - Karmakar, Gourab

AU - Guha, Pritam

AU - Roy, Biplab

AU - Besra, Shila Elizabeth

AU - Быков, Алексей Геннадьевич

AU - Акентьев, Александр Владимирович

AU - Носков, Борис Анатольевич

AU - Nag, Kaushik

AU - Jaisankar, Parasuraman

AU - Panda, Amiya Kumar

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N2 - Orcinol glucoside (OG) - loaded nanostructured lipid carrier (NLC), coated with polyethylene glycol-25/55-stearate (PEG-25/55-SA), were explored for delivering OG to improve in vitro cytotoxicity against gastrointestinal tract (GIT), colon and hepatoma carcinoma cell lines. It is being expected that the PEGylated formulations would possess the sustainability in withstanding the adverse physiological extremities like the most significant metabolic activities and phase I / II enzymatic activities in the intestines.

AB - Orcinol glucoside (OG) - loaded nanostructured lipid carrier (NLC), coated with polyethylene glycol-25/55-stearate (PEG-25/55-SA), were explored for delivering OG to improve in vitro cytotoxicity against gastrointestinal tract (GIT), colon and hepatoma carcinoma cell lines. It is being expected that the PEGylated formulations would possess the sustainability in withstanding the adverse physiological extremities like the most significant metabolic activities and phase I / II enzymatic activities in the intestines.

KW - cancer . cytotoxic activity . GIT . hepatoma . NLC .OG . PEG

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JF - Pharmaceutical Research

SN - 0724-8741

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