Numerical optimal control for HIV prevention with dynamic budget allocation

Dmitry Gromov, Ingo Bulla, Oana Silvia Serea, Ethan O. Romero-Severson

Research output

3 Citations (Scopus)

Abstract

This article is about numerical control of HIV propagation. The contribution of the article is threefold: first, a novel model of HIV propagation is proposed; second, the methods from numerical optimal control are successfully applied to the developed model to compute optimal control profiles; finally, the computed results are applied to the real problem yielding important and practically relevant results.

Original languageEnglish
Pages (from-to)469-491
Number of pages23
JournalMathematical Medicine and Biology
Volume35
Issue number4
DOIs
Publication statusPublished - 5 Dec 2018

Scopus subject areas

  • Environmental Science(all)
  • Applied Mathematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology
  • Modelling and Simulation

Cite this

Gromov, Dmitry ; Bulla, Ingo ; Serea, Oana Silvia ; Romero-Severson, Ethan O. / Numerical optimal control for HIV prevention with dynamic budget allocation. In: Mathematical Medicine and Biology. 2018 ; Vol. 35, No. 4. pp. 469-491.
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Numerical optimal control for HIV prevention with dynamic budget allocation. / Gromov, Dmitry; Bulla, Ingo; Serea, Oana Silvia; Romero-Severson, Ethan O.

In: Mathematical Medicine and Biology, Vol. 35, No. 4, 05.12.2018, p. 469-491.

Research output

TY - JOUR

T1 - Numerical optimal control for HIV prevention with dynamic budget allocation

AU - Gromov, Dmitry

AU - Bulla, Ingo

AU - Serea, Oana Silvia

AU - Romero-Severson, Ethan O.

PY - 2018/12/5

Y1 - 2018/12/5

N2 - This article is about numerical control of HIV propagation. The contribution of the article is threefold: first, a novel model of HIV propagation is proposed; second, the methods from numerical optimal control are successfully applied to the developed model to compute optimal control profiles; finally, the computed results are applied to the real problem yielding important and practically relevant results.

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KW - HIV

KW - AIDS

KW - treatment as prevention

KW - pre-exposure prophylaxis

KW - optimal control

KW - resource allocation

KW - numerical methods

KW - PREEXPOSURE PROPHYLAXIS

KW - HETEROSEXUAL MEN

KW - SEX

KW - TRANSMISSION

KW - INFECTION

KW - FRAMEWORK

KW - COHORT

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DO - 10.1093/imammb/dqx015

M3 - статья

VL - 35

SP - 469

EP - 491

JO - Mathematical Medicine and Biology

JF - Mathematical Medicine and Biology

SN - 1477-8599

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