Novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces

Viktor Korzhikov-Vlakh, Ilia Averianov, Ekaterina Sinitsyna, Yuliya Nashchekina, Dmitry Polyakov, Ivan Guryanov, Antonina Lavrentieva, Lukas Raddatz, Evgenia Korzhikova-Vlakh, Thomas Scheper, Tatiana Tennikova

Research output: Contribution to journalArticlepeer-review

3 Scopus citations
13 Downloads (Pure)

Abstract

To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly("-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-D-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands ("self-peptide" or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.

Original languageEnglish
Article number1299
JournalPolymers
Volume10
Issue number12
DOIs
StatePublished - 23 Nov 2018

Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics

Keywords

  • Biofunctionalization
  • Bioligands
  • Cells adhesion
  • Nanoparticles for drug delivery
  • PCL
  • Phagocytosis
  • PLA
  • Polyesters
  • Polyvinylsaccharide
  • Scaffolds for bone tissue engineering

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