No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes

Ioannis D. Papadimitriou, Sarah J. Lockey, Sarah Voisin, Adam J. Herbert, Fleur Garton, Peter J. Houweling, Pawel Cieszczyk, Agnieszka Maciejewska-Skrendo, Marek Sawczuk, Myosotis Massidda, Carla Maria Calò, Irina V. Astratenkova, Anastasia Kouvatsi, Anastasiya M. Druzhevskaya, Macsue Jacques, Ildus I. Ahmetov, Georgina K. Stebbings, Shane Heffernan, Stephen H. Day, Robert Erskine & 5 others Charles Pedlar, Courtney Kipps, Kathryn N. North, Alun G. Williams, Nir Eynon

Research outputpeer-review

12 Citations (Scopus)

Abstract

Background: Studies investigating associations between ACTN3 R577X and ACE I/D genotypes and endurance athletic status have been limited by small sample sizes from mixed sport disciplines and lack quantitative measures of performance. Aim: To examine the association between ACTN3 R577X and ACE I/D genotypes and best personal running times in a large homogeneous cohort of endurance runners. Methods: We collected a total of 1064 personal best 1500, 3000, 5000 m and marathon running times of 698 male and female Caucasian endurance athletes from six countries (Australia, Greece, Italy, Poland, Russia and UK). Athletes were genotyped for ACTN3 R577X and ACE ID variants. Results: There was no association between ACTN3 R577X or ACE I/D genotype and running performance at any distance in men or women. Mean (SD) marathon times (in s) were for men: ACTN3 RR 9149 (593), RX 9221 (582), XX 9129 (582) p = 0.94; ACE DD 9182 (665), ID 9214 (549), II 9155 (492) p = 0.85; for women: ACTN3 RR 10796 (818), RX 10667 (695), XX 10675 (553) p = 0.36; ACE DD 10604 (561), ID 10766 (740), II 10771 (708) p = 0.21. Furthermore, there were no associations between these variants and running time for any distance in a sub-analysis of athletes with personal records within 20% of world records. Conclusions: Thus, consistent with most case-control studies, this multi-cohort quantitative analysis demonstrates it is unlikely that ACTN3 XX genotype provides an advantage in competitive endurance running performance. For ACE II genotype, some prior studies show an association but others do not. Our data indicate it is also unlikely that ACE II genotype provides an advantage in endurance running.

Original languageEnglish
Article number13
JournalBMC Genomics
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Scopus subject areas

  • Biotechnology
  • Genetics

Cite this

Papadimitriou, I. D., Lockey, S. J., Voisin, S., Herbert, A. J., Garton, F., Houweling, P. J., ... Eynon, N. (2018). No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes. BMC Genomics, 19(1), [13]. https://doi.org/10.1186/s12864-017-4412-0
Papadimitriou, Ioannis D. ; Lockey, Sarah J. ; Voisin, Sarah ; Herbert, Adam J. ; Garton, Fleur ; Houweling, Peter J. ; Cieszczyk, Pawel ; Maciejewska-Skrendo, Agnieszka ; Sawczuk, Marek ; Massidda, Myosotis ; Calò, Carla Maria ; Astratenkova, Irina V. ; Kouvatsi, Anastasia ; Druzhevskaya, Anastasiya M. ; Jacques, Macsue ; Ahmetov, Ildus I. ; Stebbings, Georgina K. ; Heffernan, Shane ; Day, Stephen H. ; Erskine, Robert ; Pedlar, Charles ; Kipps, Courtney ; North, Kathryn N. ; Williams, Alun G. ; Eynon, Nir. / No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes. In: BMC Genomics. 2018 ; Vol. 19, No. 1.
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title = "No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes",
abstract = "Background: Studies investigating associations between ACTN3 R577X and ACE I/D genotypes and endurance athletic status have been limited by small sample sizes from mixed sport disciplines and lack quantitative measures of performance. Aim: To examine the association between ACTN3 R577X and ACE I/D genotypes and best personal running times in a large homogeneous cohort of endurance runners. Methods: We collected a total of 1064 personal best 1500, 3000, 5000 m and marathon running times of 698 male and female Caucasian endurance athletes from six countries (Australia, Greece, Italy, Poland, Russia and UK). Athletes were genotyped for ACTN3 R577X and ACE ID variants. Results: There was no association between ACTN3 R577X or ACE I/D genotype and running performance at any distance in men or women. Mean (SD) marathon times (in s) were for men: ACTN3 RR 9149 (593), RX 9221 (582), XX 9129 (582) p = 0.94; ACE DD 9182 (665), ID 9214 (549), II 9155 (492) p = 0.85; for women: ACTN3 RR 10796 (818), RX 10667 (695), XX 10675 (553) p = 0.36; ACE DD 10604 (561), ID 10766 (740), II 10771 (708) p = 0.21. Furthermore, there were no associations between these variants and running time for any distance in a sub-analysis of athletes with personal records within 20{\%} of world records. Conclusions: Thus, consistent with most case-control studies, this multi-cohort quantitative analysis demonstrates it is unlikely that ACTN3 XX genotype provides an advantage in competitive endurance running performance. For ACE II genotype, some prior studies show an association but others do not. Our data indicate it is also unlikely that ACE II genotype provides an advantage in endurance running.",
keywords = "ACE, ACTN3, Athletic performance, Champions, Endurance, Genomics",
author = "Papadimitriou, {Ioannis D.} and Lockey, {Sarah J.} and Sarah Voisin and Herbert, {Adam J.} and Fleur Garton and Houweling, {Peter J.} and Pawel Cieszczyk and Agnieszka Maciejewska-Skrendo and Marek Sawczuk and Myosotis Massidda and Cal{\`o}, {Carla Maria} and Astratenkova, {Irina V.} and Anastasia Kouvatsi and Druzhevskaya, {Anastasiya M.} and Macsue Jacques and Ahmetov, {Ildus I.} and Stebbings, {Georgina K.} and Shane Heffernan and Day, {Stephen H.} and Robert Erskine and Charles Pedlar and Courtney Kipps and North, {Kathryn N.} and Williams, {Alun G.} and Nir Eynon",
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language = "English",
volume = "19",
journal = "BMC Genomics",
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Papadimitriou, ID, Lockey, SJ, Voisin, S, Herbert, AJ, Garton, F, Houweling, PJ, Cieszczyk, P, Maciejewska-Skrendo, A, Sawczuk, M, Massidda, M, Calò, CM, Astratenkova, IV, Kouvatsi, A, Druzhevskaya, AM, Jacques, M, Ahmetov, II, Stebbings, GK, Heffernan, S, Day, SH, Erskine, R, Pedlar, C, Kipps, C, North, KN, Williams, AG & Eynon, N 2018, 'No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes', BMC Genomics, vol. 19, no. 1, 13. https://doi.org/10.1186/s12864-017-4412-0

No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes. / Papadimitriou, Ioannis D.; Lockey, Sarah J.; Voisin, Sarah; Herbert, Adam J.; Garton, Fleur; Houweling, Peter J.; Cieszczyk, Pawel; Maciejewska-Skrendo, Agnieszka; Sawczuk, Marek; Massidda, Myosotis; Calò, Carla Maria; Astratenkova, Irina V.; Kouvatsi, Anastasia; Druzhevskaya, Anastasiya M.; Jacques, Macsue; Ahmetov, Ildus I.; Stebbings, Georgina K.; Heffernan, Shane; Day, Stephen H.; Erskine, Robert; Pedlar, Charles; Kipps, Courtney; North, Kathryn N.; Williams, Alun G.; Eynon, Nir.

In: BMC Genomics, Vol. 19, No. 1, 13, 01.01.2018.

Research outputpeer-review

TY - JOUR

T1 - No association between ACTN3 R577X and ACE I/D polymorphisms and endurance running times in 698 Caucasian athletes

AU - Papadimitriou, Ioannis D.

AU - Lockey, Sarah J.

AU - Voisin, Sarah

AU - Herbert, Adam J.

AU - Garton, Fleur

AU - Houweling, Peter J.

AU - Cieszczyk, Pawel

AU - Maciejewska-Skrendo, Agnieszka

AU - Sawczuk, Marek

AU - Massidda, Myosotis

AU - Calò, Carla Maria

AU - Astratenkova, Irina V.

AU - Kouvatsi, Anastasia

AU - Druzhevskaya, Anastasiya M.

AU - Jacques, Macsue

AU - Ahmetov, Ildus I.

AU - Stebbings, Georgina K.

AU - Heffernan, Shane

AU - Day, Stephen H.

AU - Erskine, Robert

AU - Pedlar, Charles

AU - Kipps, Courtney

AU - North, Kathryn N.

AU - Williams, Alun G.

AU - Eynon, Nir

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Studies investigating associations between ACTN3 R577X and ACE I/D genotypes and endurance athletic status have been limited by small sample sizes from mixed sport disciplines and lack quantitative measures of performance. Aim: To examine the association between ACTN3 R577X and ACE I/D genotypes and best personal running times in a large homogeneous cohort of endurance runners. Methods: We collected a total of 1064 personal best 1500, 3000, 5000 m and marathon running times of 698 male and female Caucasian endurance athletes from six countries (Australia, Greece, Italy, Poland, Russia and UK). Athletes were genotyped for ACTN3 R577X and ACE ID variants. Results: There was no association between ACTN3 R577X or ACE I/D genotype and running performance at any distance in men or women. Mean (SD) marathon times (in s) were for men: ACTN3 RR 9149 (593), RX 9221 (582), XX 9129 (582) p = 0.94; ACE DD 9182 (665), ID 9214 (549), II 9155 (492) p = 0.85; for women: ACTN3 RR 10796 (818), RX 10667 (695), XX 10675 (553) p = 0.36; ACE DD 10604 (561), ID 10766 (740), II 10771 (708) p = 0.21. Furthermore, there were no associations between these variants and running time for any distance in a sub-analysis of athletes with personal records within 20% of world records. Conclusions: Thus, consistent with most case-control studies, this multi-cohort quantitative analysis demonstrates it is unlikely that ACTN3 XX genotype provides an advantage in competitive endurance running performance. For ACE II genotype, some prior studies show an association but others do not. Our data indicate it is also unlikely that ACE II genotype provides an advantage in endurance running.

AB - Background: Studies investigating associations between ACTN3 R577X and ACE I/D genotypes and endurance athletic status have been limited by small sample sizes from mixed sport disciplines and lack quantitative measures of performance. Aim: To examine the association between ACTN3 R577X and ACE I/D genotypes and best personal running times in a large homogeneous cohort of endurance runners. Methods: We collected a total of 1064 personal best 1500, 3000, 5000 m and marathon running times of 698 male and female Caucasian endurance athletes from six countries (Australia, Greece, Italy, Poland, Russia and UK). Athletes were genotyped for ACTN3 R577X and ACE ID variants. Results: There was no association between ACTN3 R577X or ACE I/D genotype and running performance at any distance in men or women. Mean (SD) marathon times (in s) were for men: ACTN3 RR 9149 (593), RX 9221 (582), XX 9129 (582) p = 0.94; ACE DD 9182 (665), ID 9214 (549), II 9155 (492) p = 0.85; for women: ACTN3 RR 10796 (818), RX 10667 (695), XX 10675 (553) p = 0.36; ACE DD 10604 (561), ID 10766 (740), II 10771 (708) p = 0.21. Furthermore, there were no associations between these variants and running time for any distance in a sub-analysis of athletes with personal records within 20% of world records. Conclusions: Thus, consistent with most case-control studies, this multi-cohort quantitative analysis demonstrates it is unlikely that ACTN3 XX genotype provides an advantage in competitive endurance running performance. For ACE II genotype, some prior studies show an association but others do not. Our data indicate it is also unlikely that ACE II genotype provides an advantage in endurance running.

KW - ACE

KW - ACTN3

KW - Athletic performance

KW - Champions

KW - Endurance

KW - Genomics

UR - http://www.scopus.com/inward/record.url?scp=85042521013&partnerID=8YFLogxK

U2 - 10.1186/s12864-017-4412-0

DO - 10.1186/s12864-017-4412-0

M3 - Article

VL - 19

JO - BMC Genomics

JF - BMC Genomics

SN - 1471-2164

IS - 1

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ER -