Abstract

Aim. To assess efficacy of a potassium channel blocker nibentan for pharmacological cardioversion of persistent atrial fibrillation. Method. Nibentan (1% solution) was infused intravenously after 3 weeks of warfarin pretreatment to 31 patients with duration of atrial fibrillation from 4 weeks to 15 months. Results. Sinus rhythm was restored in 24 patients. Mean dose of nibentan was 0.119±0.02 mg/kg. Proarrhythmic effects (paroxysmal or nonsustained polymorphic ventricular tachycardia) and substantial suppression of sinus rhythm automatism were registered in 3 and 3 patients, respectively. Conclusion. Nibentan is highly effective in persistent atrial fibrillation. It can be recommended for inhospital use in intensive care facilities.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalKardiologiya
Volume45
Issue number3
Publication statusPublished - 1 Dec 2005

Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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