N-Isocyanodialkylamines generated in situ for the Joullié–Ugi reaction with indolenines

    Research output

    3 Citations (Scopus)

    Abstract

    N-Isocyanodialkylamines are rare isocyanide surrogates for the Ugi-type reactions. To avoid problems with instability and the obnoxious smell of these reagents, we optimized and employed a convenient protocol for in situ dehydration of N,N-dialkyl-N′-formyl hydrazines to give the respective N-isocyanodialkylamines which were utilized in the reaction with indolenines and acetic acid. The reaction was demonstrated to give modest to excellent yields of products incorporating the N-isocyanodialkylamine but not the carboxylic acid component.

    Original languageEnglish
    Pages (from-to)3532-3536
    Number of pages5
    JournalTetrahedron Letters
    Volume59
    Issue number39
    DOIs
    Publication statusPublished - 26 Sep 2018

    Scopus subject areas

    • Drug Discovery
    • Biochemistry
    • Organic Chemistry

    Fingerprint Dive into the research topics of 'N-Isocyanodialkylamines generated in situ for the Joullié–Ugi reaction with indolenines'. Together they form a unique fingerprint.

  • Cite this