N-Isocyanodialkylamines generated in situ for the Joullié–Ugi reaction with indolenines

    Research output

    3 Citations (Scopus)


    N-Isocyanodialkylamines are rare isocyanide surrogates for the Ugi-type reactions. To avoid problems with instability and the obnoxious smell of these reagents, we optimized and employed a convenient protocol for in situ dehydration of N,N-dialkyl-N′-formyl hydrazines to give the respective N-isocyanodialkylamines which were utilized in the reaction with indolenines and acetic acid. The reaction was demonstrated to give modest to excellent yields of products incorporating the N-isocyanodialkylamine but not the carboxylic acid component.

    Original languageEnglish
    Pages (from-to)3532-3536
    Number of pages5
    JournalTetrahedron Letters
    Issue number39
    Publication statusPublished - 26 Sep 2018

    Scopus subject areas

    • Drug Discovery
    • Biochemistry
    • Organic Chemistry

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