Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla

Alessandro Furlan, Vyacheslav Dyachuk, Maria Eleni Kastriti, Laura Calvo-Enrique, Hind Abdo, Saida Hadjab, Tatiana Chontorotzea, Natalia Akkuratova, Dmitry Usoskin, Dmitry Kamenev, Julian Petersen, Kazunori Sunadome, Fatima Memic, Ulrika Marklund, Kaj Fried, Piotr Topilko, Francois Lallemend, Peter V. Kharchenko, Patrik Ernfors, Igor Adameyko

Research output

66 Citations (Scopus)

Abstract

Adrenaline is a fundamental circulating hormone for bodily responses to internal and external stressors. Chromaffin cells of the adrenal medulla (AM) represent the main neuroendocrine adrenergic component and are believed to differentiate from neural crest cells. We demonstrate that large numbers of chromaffin cells arise from peripheral glial stem cells, termed Schwann cell precursors (SCPs). SCPs migrate along the visceral motor nerve to the vicinity of the forming adrenal gland, where they detach from the nerve and form postsynaptic neuroendocrine chromaffin cells. An intricate molecular logic drives two sequential phases of gene expression, one unique for a distinct transient cellular state and another for cell type specification. Subsequently, these programs down-regulate SCP-gene and up-regulate chromaffin cell–gene networks. The AM forms through limited cell expansion and requires the recruitment of numerous SCPs. Thus, peripheral nerves serve as a stem cell niche for neuroendocrine system development.

Original languageEnglish
Article number46
JournalScience
Volume357
Issue number6346
DOIs
Publication statusPublished - 7 Jul 2017

Scopus subject areas

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    Furlan, A., Dyachuk, V., Kastriti, M. E., Calvo-Enrique, L., Abdo, H., Hadjab, S., Chontorotzea, T., Akkuratova, N., Usoskin, D., Kamenev, D., Petersen, J., Sunadome, K., Memic, F., Marklund, U., Fried, K., Topilko, P., Lallemend, F., Kharchenko, P. V., Ernfors, P., & Adameyko, I. (2017). Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science, 357(6346), [46]. https://doi.org/10.1126/science.aal3753