Morphological Changes In Infected Wounds Under The Influence Of Non-Thermal Atmospheric Pressure Plasma

Оксана Владимировна Рыбальченко, Ольга Геннадьевна Орлова, Александр Михайлович Астафьев, Михаил Эрнестович Пинчук, Ольга Михайловна Степанова, Елена Николаевна Парийская, Лидия Борисовна Захарова

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Abstract

Helium non-thermal atmospheric pressure plasma is now increasingly widely used in medicine for the disinfection of wounds, local treatment of cancer and skin diseases of bacterial nature. The inhibitory effect of non-thermal plasma on the growth of microorganisms with simultaneous stimulation of proliferation of wound skin cells was shown. The aim of this study was to determine the effect of helium plasma jet atmospheric pressure on the morphophysiological properties of bacteria and bacterial biofilms in infected skin wounds of animals. For the generation of non-thermal plasma, the author's development of a barrier discharge source was used. Experiments were carried out on white mongrel mice. Antimicrobial and wound healing activity of non-thermal plasma was determined at the electron microscopic level. As a result of the impact of non-thermal plasma on the skin wounds of animals shows the microbial death on the surface and in the thickness of the scab, as well as the absence of bacterial biofilms in the upper layers of the wound surface.
Original languageEnglish
Article number241
Pages (from-to)1746-7153
Number of pages8
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume9
Issue number6
Publication statusPublished - Nov 2018

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Plasma Gases
Skin
Plasmas
Helium
Wounds and Injuries
Biofilms
Animals
Plasma jets
Disinfection
Atmospheric Pressure
Microorganisms
Atmospheric pressure
Medicine
Skin Neoplasms
Bacteria
Skin Diseases
Wound Healing
Electrons
Growth
Experiments

Scopus subject areas

  • Medicine(all)

Cite this

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title = "Morphological Changes In Infected Wounds Under The Influence Of Non-Thermal Atmospheric Pressure Plasma",
abstract = "Helium non-thermal atmospheric pressure plasma is now increasingly widely used in medicine for the disinfection of wounds, local treatment of cancer and skin diseases of bacterial nature. The inhibitory effect of non-thermal plasma on the growth of microorganisms with simultaneous stimulation of proliferation of wound skin cells was shown. The aim of this study was to determine the effect of helium plasma jet atmospheric pressure on the morphophysiological properties of bacteria and bacterial biofilms in infected skin wounds of animals. For the generation of non-thermal plasma, the author's development of a barrier discharge source was used. Experiments were carried out on white mongrel mice. Antimicrobial and wound healing activity of non-thermal plasma was determined at the electron microscopic level. As a result of the impact of non-thermal plasma on the skin wounds of animals shows the microbial death on the surface and in the thickness of the scab, as well as the absence of bacterial biofilms in the upper layers of the wound surface.",
keywords = "non-thermal plasma; barrier discharge; helium plasma jet; infected wounds; antibacterial properties; bacterial biofilms; electron microscopy; wound healing.",
author = "Рыбальченко, {Оксана Владимировна} and Орлова, {Ольга Геннадьевна} and Астафьев, {Александр Михайлович} and Пинчук, {Михаил Эрнестович} and Степанова, {Ольга Михайловна} and Парийская, {Елена Николаевна} and Захарова, {Лидия Борисовна}",
year = "2018",
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AU - Рыбальченко, Оксана Владимировна

AU - Орлова, Ольга Геннадьевна

AU - Астафьев, Александр Михайлович

AU - Пинчук, Михаил Эрнестович

AU - Степанова, Ольга Михайловна

AU - Парийская, Елена Николаевна

AU - Захарова, Лидия Борисовна

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AB - Helium non-thermal atmospheric pressure plasma is now increasingly widely used in medicine for the disinfection of wounds, local treatment of cancer and skin diseases of bacterial nature. The inhibitory effect of non-thermal plasma on the growth of microorganisms with simultaneous stimulation of proliferation of wound skin cells was shown. The aim of this study was to determine the effect of helium plasma jet atmospheric pressure on the morphophysiological properties of bacteria and bacterial biofilms in infected skin wounds of animals. For the generation of non-thermal plasma, the author's development of a barrier discharge source was used. Experiments were carried out on white mongrel mice. Antimicrobial and wound healing activity of non-thermal plasma was determined at the electron microscopic level. As a result of the impact of non-thermal plasma on the skin wounds of animals shows the microbial death on the surface and in the thickness of the scab, as well as the absence of bacterial biofilms in the upper layers of the wound surface.

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