Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx

A. I. Lavrova, S. Bagyan, T. Mair, M. J.B. Hauser, L. Schimansky-Geier

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The spatio-temporal dynamics of traveling waves in glycolysis as it occurs in yeast extract have been studied, both theoretically and experimentally. We describe this phenomenon with the distributed Selkov model that accounts for the reactions of phosphofructokinase, which is a key enzyme of the glycolytic reaction cascade. To describe the experimentally observed phase waves in an open spatial reactor we introduce a non-homogeneous flux of substrate in the model. The experimental observation that waves can change their direction of propagation during the experiment is considered in the model. The mechanism for such a change in wave direction is discussed.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalBioSystems
Volume97
Issue number2
DOIs
StatePublished - 1 Aug 2009
Externally publishedYes

Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

Keywords

  • Glycolytic oscillations
  • Selkov model
  • Spatio-temporal dynamics

Fingerprint

Dive into the research topics of 'Modeling of glycolytic wave propagation in an open spatial reactor with inhomogeneous substrate influx'. Together they form a unique fingerprint.

Cite this