Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system

H. Ehrlich, T. Hanke, R. Born, C. Fischer, A. Frolov, T. Langrock, R. Hoffmann, U. Schwarzenbolz, T. Henle, P. Simon, D. Geiger, V.V. Bazhenov, H. Worch

Research output: Other contributionResearch

20 Scopus citations

Abstract

In the present work, we show for the first time, that Nɛ-carboxymethyllysine is the major product of the in vitro non-enzymatic glycation reaction between fibrillar collagen and glucuronic acid. Dual diffusion membrane system was effectively used for oriented crystal growth of octacalcium phosphate/hydroxyapatite on the biomimetically carboxymethylated collagen fibrils. We hypothesize that the function of biomimetically carboxymethylated collagen is to increase the local concentration of corresponding ions in such a way that a critical nucleus of ions can be formed, leading to the formation of the mineral under specific micro-environment conditions achieved by using diffusion membrane system.
Original languageEnglish
StatePublished - 2009
Externally publishedYes

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