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Механосенситивность различных клеток: возможная роль в регуляции и реализации эффектов физических методов лечения. / Potekhina, Yuliya P.; Filatova, A. I.; Tregubova, E. S.; Mokhov, D. E.

In: СОВРЕМЕННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ, Vol. 12, No. 4, 01.01.2020, p. 77-90.

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@article{fd5a9cd406bf4d7d8345cc66f1a183a9,
title = "Механосенситивность различных клеток: возможная роль в регуляции и реализации эффектов физических методов лечения",
abstract = "Regulatory signals in the body are not limited to chemical and electrical ones. There is another type of important signals for cells: those are mechanical signals (coming from the environment or arising from within the body), which have been less known in the literature. The review summarizes new information on the mechanosensitivity of various cells of connective tissue and nervous system. Participation of mechanical stimuli in the regulation of growth, development, differentiation, and functioning of tissues is described. The data focus on bone remodeling, wound healing, neurite growth, and the formation of neural networks. Mechanotransduction, cellular organelles, and mechanosensitive molecules involved in these processes are discussed as well as the role of the extracellular matrix. The importance of mechanical characteristics of cells in the pathogenesis of diseases is highlighted. Finally, the possible role of mechanosensitivity in mediating the physiotherapeutic effects is addressed.",
keywords = "Extracellular matrix, Mechanical stimuli, Mechanical transduction, Mechanosensitivity, Mesenchymal stem cells, Osteopathic manual therapy",
author = "Potekhina, {Yuliya P.} and Filatova, {A. I.} and Tregubova, {E. S.} and Mokhov, {D. E.}",
year = "2020",
month = jan,
day = "1",
doi = "10.17691/stm2020.12.4.10",
language = "русский",
volume = "12",
pages = "77--90",
journal = "СОВРЕМЕННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ",
issn = "2076-4243",
publisher = "Нижегородская государственная медицинская академия",
number = "4",

}

RIS

TY - JOUR

T1 - Механосенситивность различных клеток: возможная роль в регуляции и реализации эффектов физических методов лечения

AU - Potekhina, Yuliya P.

AU - Filatova, A. I.

AU - Tregubova, E. S.

AU - Mokhov, D. E.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Regulatory signals in the body are not limited to chemical and electrical ones. There is another type of important signals for cells: those are mechanical signals (coming from the environment or arising from within the body), which have been less known in the literature. The review summarizes new information on the mechanosensitivity of various cells of connective tissue and nervous system. Participation of mechanical stimuli in the regulation of growth, development, differentiation, and functioning of tissues is described. The data focus on bone remodeling, wound healing, neurite growth, and the formation of neural networks. Mechanotransduction, cellular organelles, and mechanosensitive molecules involved in these processes are discussed as well as the role of the extracellular matrix. The importance of mechanical characteristics of cells in the pathogenesis of diseases is highlighted. Finally, the possible role of mechanosensitivity in mediating the physiotherapeutic effects is addressed.

AB - Regulatory signals in the body are not limited to chemical and electrical ones. There is another type of important signals for cells: those are mechanical signals (coming from the environment or arising from within the body), which have been less known in the literature. The review summarizes new information on the mechanosensitivity of various cells of connective tissue and nervous system. Participation of mechanical stimuli in the regulation of growth, development, differentiation, and functioning of tissues is described. The data focus on bone remodeling, wound healing, neurite growth, and the formation of neural networks. Mechanotransduction, cellular organelles, and mechanosensitive molecules involved in these processes are discussed as well as the role of the extracellular matrix. The importance of mechanical characteristics of cells in the pathogenesis of diseases is highlighted. Finally, the possible role of mechanosensitivity in mediating the physiotherapeutic effects is addressed.

KW - Extracellular matrix

KW - Mechanical stimuli

KW - Mechanical transduction

KW - Mechanosensitivity

KW - Mesenchymal stem cells

KW - Osteopathic manual therapy

UR - http://www.scopus.com/inward/record.url?scp=85090252233&partnerID=8YFLogxK

U2 - 10.17691/stm2020.12.4.10

DO - 10.17691/stm2020.12.4.10

M3 - Обзорная статья

C2 - 34795996

AN - SCOPUS:85090252233

VL - 12

SP - 77

EP - 90

JO - СОВРЕМЕННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ

JF - СОВРЕМЕННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ

SN - 2076-4243

IS - 4

ER -

ID: 88336936