Research output: Contribution to journal › Review article › peer-review
Механосенситивность различных клеток: возможная роль в регуляции и реализации эффектов физических методов лечения. / Potekhina, Yuliya P.; Filatova, A. I.; Tregubova, E. S.; Mokhov, D. E.
In: СОВРЕМЕННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ, Vol. 12, No. 4, 01.01.2020, p. 77-90.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Механосенситивность различных клеток: возможная роль в регуляции и реализации эффектов физических методов лечения
AU - Potekhina, Yuliya P.
AU - Filatova, A. I.
AU - Tregubova, E. S.
AU - Mokhov, D. E.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Regulatory signals in the body are not limited to chemical and electrical ones. There is another type of important signals for cells: those are mechanical signals (coming from the environment or arising from within the body), which have been less known in the literature. The review summarizes new information on the mechanosensitivity of various cells of connective tissue and nervous system. Participation of mechanical stimuli in the regulation of growth, development, differentiation, and functioning of tissues is described. The data focus on bone remodeling, wound healing, neurite growth, and the formation of neural networks. Mechanotransduction, cellular organelles, and mechanosensitive molecules involved in these processes are discussed as well as the role of the extracellular matrix. The importance of mechanical characteristics of cells in the pathogenesis of diseases is highlighted. Finally, the possible role of mechanosensitivity in mediating the physiotherapeutic effects is addressed.
AB - Regulatory signals in the body are not limited to chemical and electrical ones. There is another type of important signals for cells: those are mechanical signals (coming from the environment or arising from within the body), which have been less known in the literature. The review summarizes new information on the mechanosensitivity of various cells of connective tissue and nervous system. Participation of mechanical stimuli in the regulation of growth, development, differentiation, and functioning of tissues is described. The data focus on bone remodeling, wound healing, neurite growth, and the formation of neural networks. Mechanotransduction, cellular organelles, and mechanosensitive molecules involved in these processes are discussed as well as the role of the extracellular matrix. The importance of mechanical characteristics of cells in the pathogenesis of diseases is highlighted. Finally, the possible role of mechanosensitivity in mediating the physiotherapeutic effects is addressed.
KW - Extracellular matrix
KW - Mechanical stimuli
KW - Mechanical transduction
KW - Mechanosensitivity
KW - Mesenchymal stem cells
KW - Osteopathic manual therapy
UR - http://www.scopus.com/inward/record.url?scp=85090252233&partnerID=8YFLogxK
U2 - 10.17691/stm2020.12.4.10
DO - 10.17691/stm2020.12.4.10
M3 - Обзорная статья
C2 - 34795996
AN - SCOPUS:85090252233
VL - 12
SP - 77
EP - 90
JO - СОВРЕМЕННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ
JF - СОВРЕМЕННЫЕ ТЕХНОЛОГИИ В МЕДИЦИНЕ
SN - 2076-4243
IS - 4
ER -
ID: 88336936