Mast cells in photolesion of the skin and basal cell cancer associated with it

I. O. Smirnova, I. M. Kvetnoy, N. M. Anichkov, O. N. Smirnova, I. V. Antonova

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Morphofunctional features of skin mast cells located in the areas subjected to chronic UV-radiation and in the associated basal cell carcinoma with photoinjure have been studied. Various immunohistochemical methods (chromogranin A, CD1a, HLA-DR, CD35, Ki67, P53, Bcl-2, Mcl-1, involucrine) were used. It is found that chronic UV-damage leads to mast cell hyperplasia as well as activation of their synthetic, absorption and secretory functions. It is suggested that mast cell hyperplasia and increase of mast cells neuroendocrine activity provide a risk of basal cell carcinoma development.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalArkhiv Patologii
Volume67
Issue number5
StatePublished - 6 Dec 2005

Scopus subject areas

  • Pathology and Forensic Medicine

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