Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads

Mikhail Krasavin, Prashant Mujumdar, Vladislav Parchinsky, Tatiana Vinogradova, Olga Manicheva, Marine Dogonadze

    Research output

    8 Citations (Scopus)

    Abstract

    A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald–Hartwig-type imidazoline arylation chemistry developed earlier. Compounds were tested for biological activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.

    Original languageEnglish
    Pages (from-to)1146-1155
    Number of pages10
    JournalJournal of Enzyme Inhibition and Medicinal Chemistry
    Volume31
    Issue number6
    DOIs
    Publication statusPublished - 1 Nov 2016

    Scopus subject areas

    • Pharmacology
    • Drug Discovery

    Fingerprint Dive into the research topics of 'Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads'. Together they form a unique fingerprint.

  • Cite this