KH-Domain Poly(C)-Binding Proteins as Versatile Regulators of Multiple Biological Processes

I. B. Nazarov, E. I. Bakhmet, A. N. Tomilin

Research output


Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include regulation of gene transcription, regulation of pre-mRNA processing, splicing, mRNA stability, translational silencing and enhancement, the control of iron turnover, and many others. Mechanistically, these proteins act via nucleic acid binding and protein-protein interactions. Through performing these multiple tasks, the KH-domain poly(C)-binding family members are involved in a wide variety of biological processes such as embryonic development, cell differentiation, and cancer. Deregulation of KH-domain protein expression is frequently associated with severe developmental defects and neoplasia. This review summarizes progress in studies of the KH-domain proteins made over past two decades. The review also reports our recent finding implying an involvement of the KH-factor Pcbp1 into control of transition from naive to primed pluripotency cell state.

Original languageEnglish
Pages (from-to)205-219
Number of pages15
JournalBiochemistry (Moscow)
Issue number3
Publication statusPublished - Mar 2019

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