“Isocyanide-less” Ugi/Intramolecular Diels-Alder reaction of 5-hydroxymethylfurfural

Research output


The one-pot, three-step, four-component Ugi-IMDAF reaction with 5-hydroxymethylfurfural provides simple access to hydroxymethyl-substituted epoxyisoindolones in a diastereoselective and stereospecific manner. The protocol avoids the transfer or isolation of isocyanides, and the broad scope was illustrated by the synthesis of 22 different compounds bearing various substituents on the heterocyclic core.

Original languageEnglish
Pages (from-to)1578-1581
JournalTetrahedron Letters
Issue number24
Early online date20 May 2019
Publication statusPublished - 13 Jun 2019

Scopus subject areas

  • Drug Discovery
  • Biochemistry
  • Organic Chemistry

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