INTERLEUKIN-18 AND RENAL ANEMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND EARLY STAGES OF CHRONIC KIDNEY DISEASE

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Abstract

INTRODUCTION: Inflammation is involved in the pathogenesis of complications of diabetes mellitus, including diabetic nephropathy and renal anemia. In this study we aimed to assess clinical correlates of serum interleukin-18 (IL-18) levels in anemic and non-anemic patients with type 2 diabetes (T2DM) and early CKD.

METHODS: We investigated 65 patients with T2DM complicated with CKD stages 1-3 (30 anemic and 35 non-anemic individuals). Anemia was defined according to WHO definition (2008). Patients with non-renal causes of anemia were not included. eGFR was calculated using CKD-EPI formula. In addition to routine clinical tests we measured serum levels of NT-proBNP and IL-18. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis.

RESULTS: We found that elevated levels of IL-18 were more prevalent in anemic patients than in individuals with normal levels of hemoglobin (20.0% vs. 2.9%, p=0.023, respectively), while there were no significant differences in eGFR, NT-proBNP, left ventricular mass index and ejection fraction between the groups. In anemic patients IL-18 correlated positively with NTproBNP (rs=0.421, p=0.036), ferritin (rs=0.430, p=0.032), and albuminuria (rs=0.479, p=0.020). However, no similar interconnections were found in patients with normal hemoglobin level. In both groups IL-18 concentration was not interconnected with age, body mass index and eGFR. The subgroup of patients with elevated ferritin levels (n=15) was characterized by strengthened correlation between IL-18 and albuminuria (rs=0.631, p=0.015).

CONCLUSIONS: The results of the study suggest that IL-18 could be involved in the pathogenesis of diabetes-related CKD and renal anemia in patients with T2DM. Serum concentration of IL-18 is interrelated with albuminuria and serum levels of NTproBNP and ferritin in anemic patients with T2DM and early CKD, but not in individuals with normal levels of hemoglobin.
Original languageEnglish
Article numberFP522
Pages (from-to)1486
Number of pages1
JournalNephrology Dialysis Transplantation
Volume34
Issue numberS1
DOIs
StatePublished - 2019
Event56th ERA-EDTA Congress, June 13-16, 2019. Budapest, Hungry - Budapest, Hungry , Budapest , Hungary
Duration: 13 Jun 201916 Jun 2019
http://Budapest, Hungry

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