INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL

S. A. Timofeev, Yu S. Tokarev, A. V. Simakova, A. A. Tsarev, V. V. Dolgikh

Research output

2 Citations (Scopus)

Abstract

Microsporidia comprise a group of fungi-related obligate intracellular eukaryotic pathogens with extremely wide host range: from protists to mammals. Adaptation to intracellular parasitism drives these parasites towards significant reduction and modification of the genome and functional apparatus, which causes extreme dependence on the host cell, as well as sophisticated host-parasite relationships. In this review we summarize our results and recent literature data about microsporidian interactions with the host at the cellular level. The impacts of these pathogens to infected cells include induction of hypertrophy, restructuring and modification of the cytoskeleton and the vesicular transport system of the host cells. Microsporidians also able to stimulate the metabolic processes in the infected cells and inhibit their defensive reactions. The main tool of the direct regulatory impact of microsporidia on the host cell apparently is the secretion of the special protein effectors capable to interfere to regulatory and signaling pathways of the host cell.

Original languageEnglish
Pages (from-to)594-601
Number of pages8
JournalTsitologiia
Volume58
Issue number8
Publication statusPublished - 1 Jan 2016

Fingerprint

Microsporidia
Host-Parasite Interactions
Host Specificity
Cytoskeleton
Hypertrophy
Mammals
Parasites
Fungi
Genome

Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Timofeev, S. A., Tokarev, Y. S., Simakova, A. V., Tsarev, A. A., & Dolgikh, V. V. (2016). INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL. Tsitologiia, 58(8), 594-601.
Timofeev, S. A. ; Tokarev, Yu S. ; Simakova, A. V. ; Tsarev, A. A. ; Dolgikh, V. V. / INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL. In: Tsitologiia. 2016 ; Vol. 58, No. 8. pp. 594-601.
@article{e8feb7e7e0444a3b9e9fc098ad7e318e,
title = "INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL",
abstract = "Microsporidia comprise a group of fungi-related obligate intracellular eukaryotic pathogens with extremely wide host range: from protists to mammals. Adaptation to intracellular parasitism drives these parasites towards significant reduction and modification of the genome and functional apparatus, which causes extreme dependence on the host cell, as well as sophisticated host-parasite relationships. In this review we summarize our results and recent literature data about microsporidian interactions with the host at the cellular level. The impacts of these pathogens to infected cells include induction of hypertrophy, restructuring and modification of the cytoskeleton and the vesicular transport system of the host cells. Microsporidians also able to stimulate the metabolic processes in the infected cells and inhibit their defensive reactions. The main tool of the direct regulatory impact of microsporidia on the host cell apparently is the secretion of the special protein effectors capable to interfere to regulatory and signaling pathways of the host cell.",
author = "Timofeev, {S. A.} and Tokarev, {Yu S.} and Simakova, {A. V.} and Tsarev, {A. A.} and Dolgikh, {V. V.}",
year = "2016",
month = "1",
day = "1",
language = "English",
volume = "58",
pages = "594--601",
journal = "Цитология",
issn = "0041-3771",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "8",

}

Timofeev, SA, Tokarev, YS, Simakova, AV, Tsarev, AA & Dolgikh, VV 2016, 'INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL', Tsitologiia, vol. 58, no. 8, pp. 594-601.

INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL. / Timofeev, S. A.; Tokarev, Yu S.; Simakova, A. V.; Tsarev, A. A.; Dolgikh, V. V.

In: Tsitologiia, Vol. 58, No. 8, 01.01.2016, p. 594-601.

Research output

TY - JOUR

T1 - INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL

AU - Timofeev, S. A.

AU - Tokarev, Yu S.

AU - Simakova, A. V.

AU - Tsarev, A. A.

AU - Dolgikh, V. V.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Microsporidia comprise a group of fungi-related obligate intracellular eukaryotic pathogens with extremely wide host range: from protists to mammals. Adaptation to intracellular parasitism drives these parasites towards significant reduction and modification of the genome and functional apparatus, which causes extreme dependence on the host cell, as well as sophisticated host-parasite relationships. In this review we summarize our results and recent literature data about microsporidian interactions with the host at the cellular level. The impacts of these pathogens to infected cells include induction of hypertrophy, restructuring and modification of the cytoskeleton and the vesicular transport system of the host cells. Microsporidians also able to stimulate the metabolic processes in the infected cells and inhibit their defensive reactions. The main tool of the direct regulatory impact of microsporidia on the host cell apparently is the secretion of the special protein effectors capable to interfere to regulatory and signaling pathways of the host cell.

AB - Microsporidia comprise a group of fungi-related obligate intracellular eukaryotic pathogens with extremely wide host range: from protists to mammals. Adaptation to intracellular parasitism drives these parasites towards significant reduction and modification of the genome and functional apparatus, which causes extreme dependence on the host cell, as well as sophisticated host-parasite relationships. In this review we summarize our results and recent literature data about microsporidian interactions with the host at the cellular level. The impacts of these pathogens to infected cells include induction of hypertrophy, restructuring and modification of the cytoskeleton and the vesicular transport system of the host cells. Microsporidians also able to stimulate the metabolic processes in the infected cells and inhibit their defensive reactions. The main tool of the direct regulatory impact of microsporidia on the host cell apparently is the secretion of the special protein effectors capable to interfere to regulatory and signaling pathways of the host cell.

UR - http://www.scopus.com/inward/record.url?scp=85038248694&partnerID=8YFLogxK

M3 - Review article

C2 - 30183199

AN - SCOPUS:85038248694

VL - 58

SP - 594

EP - 601

JO - Цитология

JF - Цитология

SN - 0041-3771

IS - 8

ER -

Timofeev SA, Tokarev YS, Simakova AV, Tsarev AA, Dolgikh VV. INTERACTIONS OF MICROSPORIDIA WITH INFECTED HOST CELL. Tsitologiia. 2016 Jan 1;58(8):594-601.