Impact of plant protein glycation in ageing and stress response: potential mechanisms, biochemistry, and biological role

A.A. Frolov, T.E. Bilova, Gagan Paudel, Uta M. Herfurth, N.G. Shilyaev, E.M. Lukasheva, Dominic Brauch, E.R Tarakhovskaya, N.V. Frolova, N.G. Osmolovskaya, Thomas Vogt, G.U. Balcke, Alain Tissier, Carsten Milkowski, Claudia Birkemeyer, Ludger A. Wessjohann

Research output: Chapter in Book/Report/Conference proceedingConference abstractsResearch

Abstract

Using in vitro peptide-based glycation models, reactivity and glycation potential of individual plant sugars were addressed and considered in the context of in vivo abundances of corresponding metabolites. Thus, approximately 800 individual AGE-modified proteins were annotated. The rates of glycation were increased under stress conditions and during the life span of experimental plants. Thereby, monosaccharide autoxidation was the major pathway of their formation, whereas dihydroxyacetone phosphate, glyceraldehyde-3-phosphate, ribulose, erythrose, and sucrose were the most probable plant AGE precursors. Analysis of α-dicarbonyl formation in model peptide-based glycation reactions performed with these sugars confirmed monosaccharide autoxidation as the principle glycation pathway in plants.

Original languageEnglish
Title of host publicationМатериалы II Международного симпозиума «Молекулярные аспекты редокс-метаболизма растений» и Международной научной школы «Роль активных форм кислорода в жизни растений» (Уфа, 26 июня – 1 июля 2017 г.)
Place of PublicationУфа
Pages38-39
StatePublished - 2017
EventII Международный симпозиум "Молекулярные аспекты редокс-метаболизма растений" и Международной научной школы " Роль активных форм кислорода в жизни растений" - Уфа, Russian Federation
Duration: 26 Jun 20171 Jul 2017
Conference number: 2
http://ofr.su/molekulyarnye-aspekty-redoks-metabolizma-rastenij

Conference

ConferenceII Международный симпозиум "Молекулярные аспекты редокс-метаболизма растений" и Международной научной школы " Роль активных форм кислорода в жизни растений"
Country/TerritoryRussian Federation
CityУфа
Period26/06/171/07/17
Internet address

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