Immunohistochemical criteria for endometrial receptivity in I/II stage endometriosis IVF-treated patients

Y. Krylova, V. Polyakova, I. Kvetnoy, I. Kogan, L. Dzhemlikhanova, D. Niauri, A. Gzgzyan, E. Ailamazyan

Research output: Contribution to journalArticle

10 Scopus citations


Background: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find a single criterion for the endometrium receptivity. Endometrium biopsy still remains the most applicable technique to diagnose abnormalities causing decrease or complete loss of endometrial receptivity. Materials and methods: We have studied 95 endometrial biopsy samples from 45 patient with I/II stage endometriosis and 40 controls from October 2014 to December 2015. Immunohistochemical analysis of key biological molecules participating in implant window formation (LIF, ER, PR, integrin, TGF-β1 and VEGF) was done to assess their predicting value for endometrial receptivity troubles. Results: The discriminant analysis demonstrated that highest information capacity was characteristic for LIF expression percent area, integrin αVβ3 both percent area and optic density in endometrial str
Original languageEnglish
Pages (from-to)33-36
JournalGynecological Endocrinology
Issue numberS2
StatePublished - 2016
Externally publishedYes


  • Endometrial receptivity
  • ER
  • implantation window
  • integrin αVβ3
  • IVF
  • LIF
  • PR
  • TGFβ1
  • VEGF


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