Immunohistochemical criteria for endometrial receptivity in I/II stage endometriosis IVF-treated patients

Y. Krylova, V. Polyakova, I. Kvetnoy, I. Kogan, L. Dzhemlikhanova, D. Niauri, A. Gzgzyan, E. Ailamazyan

Research output

7 Citations (Scopus)

Abstract

Background: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find a single criterion for the endometrium receptivity. Endometrium biopsy still remains the most applicable technique to diagnose abnormalities causing decrease or complete loss of endometrial receptivity. Materials and methods: We have studied 95 endometrial biopsy samples from 45 patient with I/II stage endometriosis and 40 controls from October 2014 to December 2015. Immunohistochemical analysis of key biological molecules participating in implant window formation (LIF, ER, PR, integrin, TGF-β1 and VEGF) was done to assess their predicting value for endometrial receptivity troubles. Results: The discriminant analysis demonstrated that highest information capacity was characteristic for LIF expression percent area, integrin αVβ3 both percent area and optic density in endometrial str
Original languageEnglish
Pages (from-to)33-36
JournalGynecological Endocrinology
Volume32
Issue numberS2
Publication statusPublished - 2016
Externally publishedYes

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Endometriosis
Fertilization in Vitro
Endometrium
Integrins
Reproductive Medicine
Biopsy
Discriminant Analysis
Vascular Endothelial Growth Factor A

Cite this

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title = "Immunohistochemical criteria for endometrial receptivity in I/II stage endometriosis IVF-treated patients",
abstract = "Background: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find a single criterion for the endometrium receptivity. Endometrium biopsy still remains the most applicable technique to diagnose abnormalities causing decrease or complete loss of endometrial receptivity. Materials and methods: We have studied 95 endometrial biopsy samples from 45 patient with I/II stage endometriosis and 40 controls from October 2014 to December 2015. Immunohistochemical analysis of key biological molecules participating in implant window formation (LIF, ER, PR, integrin, TGF-β1 and VEGF) was done to assess their predicting value for endometrial receptivity troubles. Results: The discriminant analysis demonstrated that highest information capacity was characteristic for LIF expression percent area, integrin αVβ3 both percent area and optic density in endometrial str",
keywords = "Endometrial receptivity, ER, implantation window, integrin αVβ3, IVF, LIF, PR, TGFβ1, VEGF",
author = "Y. Krylova and V. Polyakova and I. Kvetnoy and I. Kogan and L. Dzhemlikhanova and D. Niauri and A. Gzgzyan and E. Ailamazyan",
year = "2016",
language = "English",
volume = "32",
pages = "33--36",
journal = "Gynecological Endocrinology",
issn = "0951-3590",
publisher = "Taylor & Francis",
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}

TY - JOUR

T1 - Immunohistochemical criteria for endometrial receptivity in I/II stage endometriosis IVF-treated patients

AU - Krylova, Y.

AU - Polyakova, V.

AU - Kvetnoy, I.

AU - Kogan, I.

AU - Dzhemlikhanova, L.

AU - Niauri, D.

AU - Gzgzyan, A.

AU - Ailamazyan, E.

PY - 2016

Y1 - 2016

N2 - Background: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find a single criterion for the endometrium receptivity. Endometrium biopsy still remains the most applicable technique to diagnose abnormalities causing decrease or complete loss of endometrial receptivity. Materials and methods: We have studied 95 endometrial biopsy samples from 45 patient with I/II stage endometriosis and 40 controls from October 2014 to December 2015. Immunohistochemical analysis of key biological molecules participating in implant window formation (LIF, ER, PR, integrin, TGF-β1 and VEGF) was done to assess their predicting value for endometrial receptivity troubles. Results: The discriminant analysis demonstrated that highest information capacity was characteristic for LIF expression percent area, integrin αVβ3 both percent area and optic density in endometrial str

AB - Background: Implantation failure of in vitro fertilization (IVF) cycles is recognized as one of key problems in contemporary reproductive medicine. Implantation itself is a multifactorial process and one can hardly expect to find a single criterion for the endometrium receptivity. Endometrium biopsy still remains the most applicable technique to diagnose abnormalities causing decrease or complete loss of endometrial receptivity. Materials and methods: We have studied 95 endometrial biopsy samples from 45 patient with I/II stage endometriosis and 40 controls from October 2014 to December 2015. Immunohistochemical analysis of key biological molecules participating in implant window formation (LIF, ER, PR, integrin, TGF-β1 and VEGF) was done to assess their predicting value for endometrial receptivity troubles. Results: The discriminant analysis demonstrated that highest information capacity was characteristic for LIF expression percent area, integrin αVβ3 both percent area and optic density in endometrial str

KW - Endometrial receptivity

KW - ER

KW - implantation window

KW - integrin αVβ3

KW - IVF

KW - LIF

KW - PR

KW - TGFβ1

KW - VEGF

M3 - Article

VL - 32

SP - 33

EP - 36

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

SN - 0951-3590

IS - S2

ER -