Immunogenetic predictors of severe covid-19

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Immunogenetic predictors of severe covid-19. / Malkova, Anna; Kudlay, Dmitriy; Kudryavtsev, Igor ; Starshinova, Anna ; Yablonskiy, Piotr ; Shoenfeld, Yehuda.

In: Vaccines, Vol. 9, No. 3, 211, 03.2021, p. 1-13.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{56d9c469a4ac41db92ff85f4c0a6754f,

title = "Immunogenetic predictors of severe covid-19",

abstract = "According to an analysis of published data, only 20% of patients with the new coronavirus infection develop severe life-threatening complications. Currently, there are no known biomarkers, the determination of which before the onset of the disease would allow assessing the likelihood of its severe course. The purpose of this literature review was to analyze possible genetic factors characterizing the immune response to the new coronavirus infection that could be associated with the expression of angiotension-converting enzyme 2 (ACE-2) and related proteins as predictors of severe Corona virus disease 2019 (COVID-19). We analyzed original articles published in Medline, PubMed and Scopus databases from December 2019 to November 2020. For searching articles, we used the following keywords: New coronavirus infection, Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), COVID-19, severe course, complications, thrombosis, cytokine storm, ACE-2, biomarkers. In total, 3714 publications were selected using the keywords, of which 8 were in congruence with all the criteria. The literature analysis of the association of immunogenic characteristics and the expression of ACE-2 and related proteins with the development of severe COVID-19 revealed following genetic factors: HLA-B*46:01 genotype, CXCR6 gene hypoexpression, CCR9 gene expression, TLR7, rs150892504 mutations in the ERAP2 gene, overexpression of wild-type ACE-2, TMPRSS2 and its different polymorphisms. Genes, associated with the severe course, are more common among men. According to the analysis data, it can be assumed that there are population differences. However, the diagnostic significance of the markers described must be confirmed with additional clinical studies.",

keywords = "ACE-2, Biomarkers, COVID-19, Genes, HLA, Immunological parameters, New coronavirus infection, PROTEIN, genes, biomarkers, SARS CORONAVIRUS, RECEPTOR, TMPRSS2, new coronavirus infection, PATHOGENESIS, ACE2, INTERFERON, EXPRESSION, immunological parameters",

author = "Anna Malkova and Dmitriy Kudlay and Igor Kudryavtsev and Anna Starshinova and Piotr Yablonskiy and Yehuda Shoenfeld",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = mar,

doi = "10.3390/vaccines9030211",

language = "English",

volume = "9",

pages = "1--13",

journal = "Vaccines",

issn = "2076-393X",

publisher = "MDPI AG",

number = "3",

}

RIS

TY - JOUR

T1 - Immunogenetic predictors of severe covid-19

AU - Malkova, Anna

AU - Kudlay, Dmitriy

AU - Kudryavtsev, Igor

AU - Starshinova, Anna

AU - Yablonskiy, Piotr

AU - Shoenfeld, Yehuda

PY - 2021/3

Y1 - 2021/3

N2 - According to an analysis of published data, only 20% of patients with the new coronavirus infection develop severe life-threatening complications. Currently, there are no known biomarkers, the determination of which before the onset of the disease would allow assessing the likelihood of its severe course. The purpose of this literature review was to analyze possible genetic factors characterizing the immune response to the new coronavirus infection that could be associated with the expression of angiotension-converting enzyme 2 (ACE-2) and related proteins as predictors of severe Corona virus disease 2019 (COVID-19). We analyzed original articles published in Medline, PubMed and Scopus databases from December 2019 to November 2020. For searching articles, we used the following keywords: New coronavirus infection, Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), COVID-19, severe course, complications, thrombosis, cytokine storm, ACE-2, biomarkers. In total, 3714 publications were selected using the keywords, of which 8 were in congruence with all the criteria. The literature analysis of the association of immunogenic characteristics and the expression of ACE-2 and related proteins with the development of severe COVID-19 revealed following genetic factors: HLA-B*46:01 genotype, CXCR6 gene hypoexpression, CCR9 gene expression, TLR7, rs150892504 mutations in the ERAP2 gene, overexpression of wild-type ACE-2, TMPRSS2 and its different polymorphisms. Genes, associated with the severe course, are more common among men. According to the analysis data, it can be assumed that there are population differences. However, the diagnostic significance of the markers described must be confirmed with additional clinical studies.

AB - According to an analysis of published data, only 20% of patients with the new coronavirus infection develop severe life-threatening complications. Currently, there are no known biomarkers, the determination of which before the onset of the disease would allow assessing the likelihood of its severe course. The purpose of this literature review was to analyze possible genetic factors characterizing the immune response to the new coronavirus infection that could be associated with the expression of angiotension-converting enzyme 2 (ACE-2) and related proteins as predictors of severe Corona virus disease 2019 (COVID-19). We analyzed original articles published in Medline, PubMed and Scopus databases from December 2019 to November 2020. For searching articles, we used the following keywords: New coronavirus infection, Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), COVID-19, severe course, complications, thrombosis, cytokine storm, ACE-2, biomarkers. In total, 3714 publications were selected using the keywords, of which 8 were in congruence with all the criteria. The literature analysis of the association of immunogenic characteristics and the expression of ACE-2 and related proteins with the development of severe COVID-19 revealed following genetic factors: HLA-B*46:01 genotype, CXCR6 gene hypoexpression, CCR9 gene expression, TLR7, rs150892504 mutations in the ERAP2 gene, overexpression of wild-type ACE-2, TMPRSS2 and its different polymorphisms. Genes, associated with the severe course, are more common among men. According to the analysis data, it can be assumed that there are population differences. However, the diagnostic significance of the markers described must be confirmed with additional clinical studies.

KW - ACE-2

KW - Biomarkers

KW - COVID-19

KW - Genes

KW - HLA

KW - Immunological parameters

KW - New coronavirus infection

KW - PROTEIN

KW - genes

KW - biomarkers

KW - SARS CORONAVIRUS

KW - RECEPTOR

KW - TMPRSS2

KW - new coronavirus infection

KW - PATHOGENESIS

KW - ACE2

KW - INTERFERON

KW - EXPRESSION

KW - immunological parameters

UR - http://www.scopus.com/inward/record.url?scp=85102705814&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/aba6abc5-6f5c-3e2e-a4a8-efe4f5f119ce/

U2 - 10.3390/vaccines9030211

DO - 10.3390/vaccines9030211

M3 - Review article

AN - SCOPUS:85102705814

VL - 9

SP - 1

EP - 13

JO - Vaccines

JF - Vaccines

SN - 2076-393X

IS - 3

M1 - 211

ER -

ID: 87711073