Hyperhomocysteinemia in men with metabolic syndrome and early stages of chronic kidney disease

N. V. Hudiakova, I. Y. Pchelin, A. N. Shishkin, V. V. Smirnov, N. V. Ivanov, M. V. Makarenko, V. K. Bayrasheva, K. G. Staroselsky

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective. We investigated homocysteine metabolism in men with early stages of chronic kidney disease (CKD) and metabolic syndrome (MS). Design and methods. A total of 79 men were selected and divided into two groups, i. e. CKD C1-C2 degree and MS with abnormal carbohydrate metabolism (main group, n = 44) and CKD C1-C2 degree and MS with normal carbohydrate metabolism (control group, n = 35). We assessed serum levels of fasting and postprandial glucose, HbA1c, insulin, C-peptide, homocysteine. We also studied polymorphisms of the genes encoding homocysteine metabolism-related enzymes. Results. 82,3 % patients had elevated serum levels of homocysteine with no significant differences between the groups. 90,0 % cases of hyperhomocysteinemia (HHC) in men with CKD C1-C2 degree and MS were associated with polymorphism of the genes encoding homocysteine metabolism-related enzymes. In men with CKD C1-C2 degree and MS with normal carbohydrate metabolism we found positive correlations between creatinine and homocysteine (rs = 0,4; p < 0,05). Conclusions. The majority of men with MS and CKD C1-C2 degree have hyperhomocysteinemia that is usually determined by genetic factors. Serum level of homocysteine at the initial stages of renal dysfunction does not depend on the state of carbohydrate metabolism in MS.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalArterial Hypertension (Russian Federation)
Volume23
Issue number2
DOIs
StatePublished - 1 Jan 2017

Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Keywords

  • Chronic kidney disease
  • Hyperhomocysteinemia
  • Metabolic syndrome
  • MTHFR (EC 1.5.1.20)
  • MTR (EC 2.1.1.13)
  • Polymorphisms of genes of MTRR (EC 1.16.1.8)

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