Hox genes and animal regeneration

E. L. Novikova, N. I. Bakalenko, A. Y. Nesterenko, M. A. Kulakova

Research output

1 Citation (Scopus)


The concept of regeneration is intimately associated with ideas about positional information, that is, the distribution of various signals prescribing cells their location in an embryo or an adult organism. Hox genes are perfect candidates for the role of factors creating positional information. Their main function is thought to be regionalization of the embryo and the determination of the anterior/posterior (A/P) axis of the bilaterian body according to the rules of temporal and spatial colinearity. At the same time, Hox genes are also expressed postembryonically and may participate in various processes in the adult body. In particular, Hox genes are involved in regeneration, as shown on animals from different evolutionary clades. During reparation Hox genes are responsible for regionalization and specification of the newly formed structures, which reflects their embryonic role. This is not all, however. Hox transcription patterns in some adult organisms and their expression dynamics after damage suggest tha
Original languageEnglish
Pages (from-to)pp 173–180
JournalRussian Journal of Developmental Biology
Issue number4
Publication statusPublished - 2016

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