Host-dependent serum specificity to the V3 domain of HIV-1

A. A. Nabatov, A. E. Masharsky, S. V. Verevochkin, A. V. Emelyanov, A. P. Kozlov

Research output

2 Citations (Scopus)

Abstract

The previous studies of anti-HIV-1 humoral immune response have found the stable individual structural bias in the antibody production that reflects the changes in the immune functional network caused by HIV-1. The correlation between antigen structure, in particular the V3 domain of HIV-1, and the serum specificity to the structure remains unclear. To clarify the role of host individual factors in the serum specificity, we used the slightly modified HIV-1 serotyping methodological approach for the sera of the patients infected with HIV-1 with a different level of genetic similarity. Substantial discrepancy between serum specificities and antigen structure was found. Patients infected with HIV-1 carrying similar and identical V3 sequences had significantly different serum specificities. The opposite situation was often observed as well. The results of the study suggest that the influence of the V3 loop structure in the development of humoral immune response to the V3 loop is substantially modified in a patient-specific manner.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
JournalScandinavian Journal of Immunology
Volume60
Issue number5
DOIs
Publication statusPublished - 1 Nov 2004

Scopus subject areas

  • Immunology

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