Heteromolecular compounds in binary systems of amino acids with opposite and same chiralities

Anton I. Isakov, Heike Lorenz, Andrey A. Zolotarev, Elena N. Kotelnikova

Research outputpeer-review

Abstract

A classification of discrete compounds in binary chiral systems of single and different substances (homo- A nd heteromolecular compounds) is presented. It considers both chemical and crystallographic characteristics of such compounds. Using amino acids as chiral model systems, features of crystal structures of equimolar and non-equimolar heteromolecular compounds are reviewed. In this connection, the concept of homo- A nd heteromolecular dimers in compounds formed by amino acids is introduced and analyzed. As a result, a correlation between the molecular dimer type and the side chain structure (linear or branched) and the conformation (extended or folded) of the relevant compounds' molecules is derived. Two non-equimolar discrete heterocompounds discovered in the chiral systems l-valine-l-isoleucine and l-valine-l-leucine are discussed using the concepts proposed. The previously studied first system features a 2:1 (Val:Ile) compound. A newly investigated second system is found to form a 3:1 (Val:Leu) compound, and its crystal structure is described and evaluated.

Original languageEnglish
Pages (from-to)986-997
Number of pages12
JournalCrystEngComm
Volume22
Issue number5
Early online date14 Jan 2020
DOIs
Publication statusPublished - 7 Feb 2020

Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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