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Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics. / Shevtsov, Maxim; Stangl, Stefan; Nikolaev, Boris; Yakovleva, Ludmila; Marchenko, Yaroslav; Tagaeva, Ruslana; Sievert, Wolfgang; Pitkin, Emil; Mazur, Anton; Tolstoy, Peter; Galibin, Oleg; Ryzhov, Vyacheslav; Steiger, Katja; Smirnov, Oleg; Khachatryan, William; Chester, Kerry; Multhoff, Gabriele.

In: Small, Vol. 15, No. 13, 1900205, 27.03.2019, p. e1900205.

Research output: Contribution to journal › Article › peer-review

Harvard

Shevtsov, M, Stangl, S, Nikolaev, B, Yakovleva, L, Marchenko, Y, Tagaeva, R, Sievert, W, Pitkin, E, Mazur, A, Tolstoy, P, Galibin, O, Ryzhov, V, Steiger, K, Smirnov, O, Khachatryan, W, Chester, K & Multhoff, G 2019, 'Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics', Small, vol. 15, no. 13, 1900205, pp. e1900205. https://doi.org/10.1002/smll.201900205

APA

Shevtsov, M., Stangl, S., Nikolaev, B., Yakovleva, L., Marchenko, Y., Tagaeva, R., Sievert, W., Pitkin, E., Mazur, A., Tolstoy, P., Galibin, O., Ryzhov, V., Steiger, K., Smirnov, O., Khachatryan, W., Chester, K., & Multhoff, G. (2019). Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics. Small, 15(13), e1900205. [1900205]. https://doi.org/10.1002/smll.201900205

Vancouver

Shevtsov M, Stangl S, Nikolaev B, Yakovleva L, Marchenko Y, Tagaeva R et al. Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics. Small. 2019 Mar 27;15(13):e1900205. 1900205. https://doi.org/10.1002/smll.201900205

Author

Shevtsov, Maxim ; Stangl, Stefan ; Nikolaev, Boris ; Yakovleva, Ludmila ; Marchenko, Yaroslav ; Tagaeva, Ruslana ; Sievert, Wolfgang ; Pitkin, Emil ; Mazur, Anton ; Tolstoy, Peter ; Galibin, Oleg ; Ryzhov, Vyacheslav ; Steiger, Katja ; Smirnov, Oleg ; Khachatryan, William ; Chester, Kerry ; Multhoff, Gabriele. / Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics. In: Small. 2019 ; Vol. 15, No. 13. pp. e1900205.

BibTeX

@article{11821e7e9099467da47dad9197f5c9d1,
title = "Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics",
abstract = "Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as potential clinical tools for cancer theranostics. Membrane-bound 70 kDa heat shock protein (mHsp70) is ubiquitously expressed on the cell membrane of various tumor types but not normal cells and therefore provides a tumor-specific target. The serine protease granzyme B (GrB) that is produced as an effector molecule by activated T and NK cells has been shown to specifically target mHsp70 on tumor cells. Following binding to Hsp70, GrB is rapidly internalized into tumor cells. Herein, it is demonstrated that GrB functionalized SPIONs act as a contrast enhancement agent for magnetic resonance imaging and induce specific tumor cell apoptosis. Combinatorial regimens employing stereotactic radiotherapy and/or magnetic targeting are found to further enhance the therapeutic efficacy of GrB-SPIONs in different tumor mouse models.",
keywords = "glioblastoma, granzyme B, magnetic targeting, radiotherapy, superparamagnetic nanoparticles, IRON-OXIDE NANOPARTICLES, BOUND HEAT-SHOCK-PROTEIN-70, CELLS, MOUSE-TUMORS, MAGNETIC NANOPARTICLES, HEAT-SHOCK-PROTEIN, DELIVERY, SURFACE, HEAT-SHOCK-PROTEIN-70 HSP70, EXPRESSION",
author = "Maxim Shevtsov and Stefan Stangl and Boris Nikolaev and Ludmila Yakovleva and Yaroslav Marchenko and Ruslana Tagaeva and Wolfgang Sievert and Emil Pitkin and Anton Mazur and Peter Tolstoy and Oleg Galibin and Vyacheslav Ryzhov and Katja Steiger and Oleg Smirnov and William Khachatryan and Kerry Chester and Gabriele Multhoff",
year = "2019",
month = mar,
day = "27",
doi = "10.1002/smll.201900205",
language = "English",
volume = "15",
pages = "e1900205",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-Blackwell",
number = "13",

}

RIS

TY - JOUR

T1 - Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics

AU - Shevtsov, Maxim

AU - Stangl, Stefan

AU - Nikolaev, Boris

AU - Yakovleva, Ludmila

AU - Marchenko, Yaroslav

AU - Tagaeva, Ruslana

AU - Sievert, Wolfgang

AU - Pitkin, Emil

AU - Mazur, Anton

AU - Tolstoy, Peter

AU - Galibin, Oleg

AU - Ryzhov, Vyacheslav

AU - Steiger, Katja

AU - Smirnov, Oleg

AU - Khachatryan, William

AU - Chester, Kerry

AU - Multhoff, Gabriele

PY - 2019/3/27

Y1 - 2019/3/27

N2 - Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as potential clinical tools for cancer theranostics. Membrane-bound 70 kDa heat shock protein (mHsp70) is ubiquitously expressed on the cell membrane of various tumor types but not normal cells and therefore provides a tumor-specific target. The serine protease granzyme B (GrB) that is produced as an effector molecule by activated T and NK cells has been shown to specifically target mHsp70 on tumor cells. Following binding to Hsp70, GrB is rapidly internalized into tumor cells. Herein, it is demonstrated that GrB functionalized SPIONs act as a contrast enhancement agent for magnetic resonance imaging and induce specific tumor cell apoptosis. Combinatorial regimens employing stereotactic radiotherapy and/or magnetic targeting are found to further enhance the therapeutic efficacy of GrB-SPIONs in different tumor mouse models.

AB - Functionalized superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as potential clinical tools for cancer theranostics. Membrane-bound 70 kDa heat shock protein (mHsp70) is ubiquitously expressed on the cell membrane of various tumor types but not normal cells and therefore provides a tumor-specific target. The serine protease granzyme B (GrB) that is produced as an effector molecule by activated T and NK cells has been shown to specifically target mHsp70 on tumor cells. Following binding to Hsp70, GrB is rapidly internalized into tumor cells. Herein, it is demonstrated that GrB functionalized SPIONs act as a contrast enhancement agent for magnetic resonance imaging and induce specific tumor cell apoptosis. Combinatorial regimens employing stereotactic radiotherapy and/or magnetic targeting are found to further enhance the therapeutic efficacy of GrB-SPIONs in different tumor mouse models.

KW - glioblastoma

KW - granzyme B

KW - magnetic targeting

KW - radiotherapy

KW - superparamagnetic nanoparticles

KW - IRON-OXIDE NANOPARTICLES

KW - BOUND HEAT-SHOCK-PROTEIN-70

KW - CELLS

KW - MOUSE-TUMORS

KW - MAGNETIC NANOPARTICLES

KW - HEAT-SHOCK-PROTEIN

KW - DELIVERY

KW - SURFACE

KW - HEAT-SHOCK-PROTEIN-70 HSP70

KW - EXPRESSION

UR - http://www.scopus.com/inward/record.url?scp=85062364915&partnerID=8YFLogxK

U2 - 10.1002/smll.201900205

DO - 10.1002/smll.201900205

M3 - Article

C2 - 30828968

AN - SCOPUS:85062364915

VL - 15

SP - e1900205

JO - Small

JF - Small

SN - 1613-6810

IS - 13

M1 - 1900205

ER -

ID: 43112175