Functional properties of smooth muscle cells in ascending aortic aneurysm

D.A. Kostina, I.V. Voronkina, L.V. Smagina, N.D. Gavriliuk, O.M. Moiseeva, O.B. Irtiuga, V.E. Uspensky, A.A. Kostareva, A.B. Malashicheva

Research output

3 Citations (Scopus)

Abstract

Thoracic aortic aneurism (TAA) develops as a result of complex series of events that dynamically alter the structure and composition of the aortic vascular extracellular matrix (ECM). The main elements that alter the composition of aortic wall are smooth muscle cells (SMC). The purpose of the present work was to study alteration of smooth muscle cell functions derived from the patients with TAA and from healthy donors. As it is supposed that TAA associated with bicuspid aortic valve (BAV) and with tricuspid aortic valve (TAV) differ in their pathogenesis, we compared the SMC and tissues samples from BAV-, TAV-patients and healthy donors. We compared TAA patients' derived tissues and SMC to healthy donors' ones in several parameters: SMC growth, migration and apoptotic dynamics; metalloproteinase MMP2 and MMP9 activity (zymography) and elastin, collagen and fibrillin content (Western blot) in both tissue samples and cultured SMC. Proliferation ability of both BAV and TAV SMC was decreased comparing to donors c
Original languageRussian
Pages (from-to)725-731
JournalЦитология
Issue number10
Publication statusPublished - 2013

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