Frequency-contrast sensitivity of visual stimulus perception in patients with schizophrenia treated with atypical and typical antipsychotics

I. I. Shoshina, Yu E. Shelepin, N. B. Semenova

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The effects of typical and atypical antipsychotics on the perception of visual stimuli that preferentially activate magnocellular or parvocellular visual channels have been studied. The threshold contrast sensitivity in healthy individuals and patients with schizophrenia has been recorded. The Gabor-like sinusoidal brightness gratings and spatial frequencies of 0.4, 3.6, and 17.9 cycles/degree were presented to the tested objects. The patients were divided into two groups, one receiving the therapy with atypical antipsychotics, and the other, with typical ones. The contrast sensitivity for low and medium spatial frequencies (i.e., for the stimuli corresponding to magnocellular channels) decreased compared to the norm. Note that the decrease in the contrast sensitivity for the low spatial frequencies in the patients treated with atypical antipsychotics is significantly more pronounced compared to the cohort that received typical antipsychotics.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalHuman Physiology
Volume40
Issue number1
DOIs
StatePublished - 1 Jan 2014

Scopus subject areas

  • Physiology
  • Physiology (medical)

Keywords

  • contrast-frequency sensitivity
  • dopamine
  • Gabor elements
  • parvocellular and magnocellular visual channels
  • schizophrenia
  • serotonin
  • typical and atypical antipsychotics
  • visual perception

Fingerprint Dive into the research topics of 'Frequency-contrast sensitivity of visual stimulus perception in patients with schizophrenia treated with atypical and typical antipsychotics'. Together they form a unique fingerprint.

Cite this