Fluorescent Ag-Nanoclusters for Evaluation of Serum Albumin and Immunoglobulin Concentrations in Protein Mixtures

A. V. Mizincev, T. S. Sych, A. M. Polyanichko, L. V. Plotnikova, A. D. Garifullin, S. V. Voloshin, A. I. Kononov

Research output: Contribution to journalArticlepeer-review

Abstract

In this work we designed, synthesized and characterized luminescent metal nanoclusters (NCs) on human serum albumin (HSA) and immunoglobulins (Ig). We demonstrate that the approach developed allows one to determine the relative content of albumins and immunoglobulins in biologically relevant protein mixtures based on the luminescent properties of the NCs. Fast and inexpensive approach which allows to determine concentrations of immunoglobulins (Ig) and serum albumin (HSA) in blood serum might be useful in clinical diagnostics.

Original languageEnglish
Article number012061
JournalJournal of Physics: Conference Series
Volume1695
DOIs
StatePublished - 2020
Event7th International School and Conference "Saint-Petersburg OPEN 2020" on Optoelectronics, Photonics, Engineering and Nanostructures - Санкт-Петербург, Russian Federation
Duration: 26 Apr 202030 Apr 2020

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