Features of DNA Repair in the Early Stages of Mammalian Embryonic Development.

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Abstract

Cell repair machinery is responsible for protecting the genome from endogenous and exogenous effects that induce DNA damage. Mutations that occur in somatic cells lead to dysfunction in certain tissues or organs, while a violation of genomic integrity during the embryonic period often leads to death. A mammalian embryo’s ability to respond to damaged DNA and repair it, as well as its sensitivity to specific lesions, is still not well understood. In this review, we combine disparate data on repair processes in the early stages of preimplantation development in mammalian embryos
Original languageEnglish
Article number1138
Number of pages11
JournalGenes
Volume11
Issue number10
DOIs
StatePublished - 27 Sep 2020

Keywords

  • DNA repair
  • BER (base excision repair)
  • NER (nucleotide excision repair)
  • MMR (mismatch repair)
  • DSBR (double strand break repair)
  • HR (homologous recombination)
  • NHEJ (nonhomologous end joining)
  • MHEJ (microhomologies end joining)
  • oocyte
  • zygote
  • Blastocyst

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