Facile entry into structurally diverse, privileged, (hetero)arene-fused N-alkoxy 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-ones

Alexander Sapegin, Elena Reutskaya, Alexey Smirnov, Mikhail Korsakov, Mikhail Krasavin

    Research output

    10 Citations (Scopus)


    Rare and highly medicinally relevant N-alkoxy-substituted benzo[1,4]oxazepines have been synthesized conveniently via the base-promoted SNAr/Smiles rearrangement/SNAr tandem cyclization of N-alkoxysalicylamides with a range of bis-electrophilic substrates; subsequent de-alkylation gives rise to the respective N-hydroxy versions. The compounds reported herein significantly add to the contemporary arsenal of small molecule tools for drug discovery. (C) 2016 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)5877-5880
    Number of pages4
    JournalTetrahedron Letters
    Issue number52
    Publication statusPublished - 28 Dec 2016

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