Expression of thrombospondin-1 gene mRNA and protein in the placenta in gestosis

Yu V. Ostankova, Ya S. Klimovskaya, O. A. Gorskaya, A. V. Kolobov, I. M. Kvetnoi, S. A. Selkov, D. I. Sokolov

Research output

7 Citations (Scopus)

Abstract

The expression of TSP-1 gene mRNA and TSP-1 protein in the placental tissue was studied during normal pregnancy and in gestosis. The formation of placental tissue in normal gestation was associated with expression of TSP-1 gene mRNA and of TSP-1 protein. Gestosis was associated with infl ammatory reaction in the placenta characterized by increased counts of lymphocytes and macrophages in the villous stroma and involution degenerative changes in tissue. Disorders in placental villi maturation and branching in gestosis were paralleled by hyperexpression of TSP-1 gene mRNA by placental cells and hyperexpression of TSP-1 protein predominating in the stromal elements of terminal villi and near villous vessels.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume151
Issue number2
DOIs
Publication statusPublished - 1 Jun 2011

Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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