Employing α-Diazocarbonyl Compound Chemistry in the Assembly of Medicinally Important Aryl(alkyl)thiolactam Scaffold

Research outputpeer-review

5 Citations (Scopus)

Abstract

RH2(OAc)4-catalyzed coupling of α-diazo-γ-butyrolactams with a wide range of aliphatic and aromatic thiols leads to α-aryl(alkyl)thiolactams in generally good yields. The transformation was found to be tolerant to sterically hindered thiols in contrast to analogous O–H insertion. Moreover, the same diazo lactams can be easily converted to β-aryl(alkyl)thiolactams in two steps using one-pot protocol. Consequently, the continued synthetic exploration of α-diazo-γ-butyrolactams paves the way toward two medicinally important scaffolds.

Original languageEnglish
Pages (from-to)5798-5800
JournalEuropean Journal of Organic Chemistry
Volume2019
Issue number33
Early online date26 Jul 2019
DOIs
Publication statusPublished - 8 Sep 2019

Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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