Efficient Suzuki-Miyaura mono-arylation of symmetrical diiodo(hetero)arenes

    Research output

    2 Citations (Scopus)

    Abstract

    A reliable protocol for converting 1,4-diiodo-2,3,5,6-tetrafluorobenzene into 1-(hetero)aryl-4-iodo-2,3,5,6-tetrafluorobenzene derivatives has been lacking in the literature. We have identified optimal conditions to achieve this conversion in good yields and have minimized formation of the bis-coupling product. The newly identified protocol involving the use of a syringe pump has been extended to other symmetrical diiodo(hetero)arenes.

    Original languageEnglish
    Pages (from-to)1948-1951
    Number of pages4
    JournalTetrahedron Letters
    Volume59
    Issue number20
    DOIs
    Publication statusPublished - 16 May 2018

    Scopus subject areas

    • Drug Discovery
    • Biochemistry
    • Organic Chemistry

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