Efficient cyclodehydration of dicarboxylic acids with oxalyl chloride

Grigory Kantin, Evgeny Chupakhin, Dmitry Dar'in, Mikhail Krasavin

Research output

11 Citations (Scopus)


Literature examples illustrating the use of oxalyl chloride to prepare dicarboxylic acid anhydrides are surprisingly limited. At the same time, we have discovered a method involving the use of this readily available reagent which allowed the preparation of novel cyclic anhydrides where other, more conventional, methods had failed. Herein, we demonstrate that the method is applicable to a wide diversity of substrates, delivers good to excellent yields of cyclic anhydrides without chromatographic purification and can be considered a synthetic tool of choice whenever dicarboxylic acid cyclodehydration is required.

Original languageEnglish
Pages (from-to)3160-3163
Number of pages4
JournalTetrahedron Letters
Issue number32
Publication statusPublished - 1 Jan 2017

Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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