Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells

D. I. Sokolov, T. Yu. Lvova, L. S. Okorokova, Ksenia Lvovna Belyakova, A. R. Sheveleva, O. I. Stepanova, V. A. Mikhailova, S. A. Sel'kov

    Research output

    3 Citations (Scopus)

    Abstract

    Despite ample data on cytokine secretion in the uteroplacental interface, the influence of microenvironment cells, in particular, trophoblast cells on angiogenesis and the role of cytokines in this process remain poorly studied. We studied the influence of cytokines on the formation of tube-like structures by endothelial cells in the presence of trophoblast cells and showed that trophoblast cells suppressed the angiogenic potential of endothelial cells. Antiangiogenic cytokines IFN-gamma, IL-10, TNF-alpha, and TGF beta via modulation of trophoblast cells stimulated the formation of tube-like structures by endothelial cells. In the co-culture of endothelial and trophoblast cells, the effects of cytokines changed and they gained additional regulatory functions.

    Original languageEnglish
    Pages (from-to)148-158
    Number of pages11
    JournalBulletin of Experimental Biology and Medicine
    Volume163
    Issue number1
    DOIs
    Publication statusPublished - May 2017

    Fingerprint

    Endothelial cells
    Trophoblasts
    Endothelial Cells
    Cytokines
    Cellular Microenvironment
    Lymphotoxin-alpha
    Coculture Techniques
    Cell culture
    Transforming Growth Factor beta
    Interleukin-10
    Tumor Necrosis Factor-alpha
    Modulation

    Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Sokolov, D. I. ; Lvova, T. Yu. ; Okorokova, L. S. ; Belyakova, Ksenia Lvovna ; Sheveleva, A. R. ; Stepanova, O. I. ; Mikhailova, V. A. ; Sel'kov, S. A. / Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells. In: Bulletin of Experimental Biology and Medicine. 2017 ; Vol. 163, No. 1. pp. 148-158.
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    abstract = "Despite ample data on cytokine secretion in the uteroplacental interface, the influence of microenvironment cells, in particular, trophoblast cells on angiogenesis and the role of cytokines in this process remain poorly studied. We studied the influence of cytokines on the formation of tube-like structures by endothelial cells in the presence of trophoblast cells and showed that trophoblast cells suppressed the angiogenic potential of endothelial cells. Antiangiogenic cytokines IFN-gamma, IL-10, TNF-alpha, and TGF beta via modulation of trophoblast cells stimulated the formation of tube-like structures by endothelial cells. In the co-culture of endothelial and trophoblast cells, the effects of cytokines changed and they gained additional regulatory functions.",
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    author = "Sokolov, {D. I.} and Lvova, {T. Yu.} and Okorokova, {L. S.} and Belyakova, {Ksenia Lvovna} and Sheveleva, {A. R.} and Stepanova, {O. I.} and Mikhailova, {V. A.} and Sel'kov, {S. A.}",
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    Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells. / Sokolov, D. I.; Lvova, T. Yu.; Okorokova, L. S.; Belyakova, Ksenia Lvovna; Sheveleva, A. R.; Stepanova, O. I.; Mikhailova, V. A.; Sel'kov, S. A.

    In: Bulletin of Experimental Biology and Medicine, Vol. 163, No. 1, 05.2017, p. 148-158.

    Research output

    TY - JOUR

    T1 - Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells

    AU - Sokolov, D. I.

    AU - Lvova, T. Yu.

    AU - Okorokova, L. S.

    AU - Belyakova, Ksenia Lvovna

    AU - Sheveleva, A. R.

    AU - Stepanova, O. I.

    AU - Mikhailova, V. A.

    AU - Sel'kov, S. A.

    PY - 2017/5

    Y1 - 2017/5

    N2 - Despite ample data on cytokine secretion in the uteroplacental interface, the influence of microenvironment cells, in particular, trophoblast cells on angiogenesis and the role of cytokines in this process remain poorly studied. We studied the influence of cytokines on the formation of tube-like structures by endothelial cells in the presence of trophoblast cells and showed that trophoblast cells suppressed the angiogenic potential of endothelial cells. Antiangiogenic cytokines IFN-gamma, IL-10, TNF-alpha, and TGF beta via modulation of trophoblast cells stimulated the formation of tube-like structures by endothelial cells. In the co-culture of endothelial and trophoblast cells, the effects of cytokines changed and they gained additional regulatory functions.

    AB - Despite ample data on cytokine secretion in the uteroplacental interface, the influence of microenvironment cells, in particular, trophoblast cells on angiogenesis and the role of cytokines in this process remain poorly studied. We studied the influence of cytokines on the formation of tube-like structures by endothelial cells in the presence of trophoblast cells and showed that trophoblast cells suppressed the angiogenic potential of endothelial cells. Antiangiogenic cytokines IFN-gamma, IL-10, TNF-alpha, and TGF beta via modulation of trophoblast cells stimulated the formation of tube-like structures by endothelial cells. In the co-culture of endothelial and trophoblast cells, the effects of cytokines changed and they gained additional regulatory functions.

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    KW - IN-VITRO

    KW - EXTRAVILLOUS TROPHOBLAST

    KW - INTERFERON-GAMMA

    KW - MATRIX METALLOPROTEINASES

    KW - PREECLAMPTIC PREGNANCIES

    KW - MESSENGER-RNA

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