Dopamine transporter mutant animals: a translational perspective

EV Efimova, RR Gainetdinov, EA Budygin, TD Sotnikova

Research output

15 Citations (Scopus)

Abstract

The dopamine transporter (DAT) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. Since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered DAT function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. In this brief overview, we discuss recent investigations involving animals with genetically altered DAT function, particularly focusing on translational studies providing new insights into pathology and pharmacology of dopamine-related disorders. Perspective applications of these and newly developed models of DAT dysfunction are also discussed.
Original languageUndefined
JournalJournal of Neurogenetics
Publication statusPublished - 2016
Externally publishedYes

Cite this

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title = "Dopamine transporter mutant animals: a translational perspective",
abstract = "The dopamine transporter (DAT) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. Since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered DAT function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. In this brief overview, we discuss recent investigations involving animals with genetically altered DAT function, particularly focusing on translational studies providing new insights into pathology and pharmacology of dopamine-related disorders. Perspective applications of these and newly developed models of DAT dysfunction are also discussed.",
keywords = "Addiction, Parkinson’s disease, attention deficit hyperactivity disorder, dopamine transporter, knockout, schizophrenia",
author = "EV Efimova and RR Gainetdinov and EA Budygin and TD Sotnikova",
year = "2016",
language = "не определен",
journal = "Journal of Neurogenetics",
issn = "0167-7063",
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TY - JOUR

T1 - Dopamine transporter mutant animals: a translational perspective

AU - Efimova, EV

AU - Gainetdinov, RR

AU - Budygin, EA

AU - Sotnikova, TD

PY - 2016

Y1 - 2016

N2 - The dopamine transporter (DAT) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. Since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered DAT function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. In this brief overview, we discuss recent investigations involving animals with genetically altered DAT function, particularly focusing on translational studies providing new insights into pathology and pharmacology of dopamine-related disorders. Perspective applications of these and newly developed models of DAT dysfunction are also discussed.

AB - The dopamine transporter (DAT) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. Since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered DAT function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. In this brief overview, we discuss recent investigations involving animals with genetically altered DAT function, particularly focusing on translational studies providing new insights into pathology and pharmacology of dopamine-related disorders. Perspective applications of these and newly developed models of DAT dysfunction are also discussed.

KW - Addiction

KW - Parkinson’s disease

KW - attention deficit hyperactivity disorder

KW - dopamine transporter

KW - knockout

KW - schizophrenia

M3 - Обзор литературы

JO - Journal of Neurogenetics

JF - Journal of Neurogenetics

SN - 0167-7063

ER -