Disturbance in mammalian cognition caused by accumulation of silver in brain

Anna A. Antsiferova, Marina Yu Kopaeva, Vyacheslav N. Kochkin, Pavel K. Kashkarov, Mikhail V. Kovalchuk

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.

Original languageEnglish
Article number30
Pages (from-to)1-13
Number of pages13
JournalToxics
Volume9
Issue number2
DOIs
StatePublished - Feb 2021
Externally publishedYes

Scopus subject areas

  • Toxicology
  • Chemical Health and Safety
  • Health, Toxicology and Mutagenesis

Keywords

  • Accumulation in brain
  • Biodistribution
  • CA2
  • Cerebellum
  • Contextual memory
  • Cortex
  • Fear
  • Hip-pocampus
  • Neutron activation analysis
  • Silver nanoparticles

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