As described for the first time in 1974 by Olah, diazo function can be directly converted to a combination of a fluorine atom with other substituents (such as hydrogen atom, another fluorine atom, other halogens, oxy or amino substituents or an aromatic ring). These reactions offer a direct entry into novel fluorinated scaffolds via metal-catalyzed or metal-free reactions. Some of these methods can be adopted to the stringent requirements of producing short-lived 18F tracers for positron emission tomography. The full range of literature (1974–2020) on the topic is reviewed in this digest.

Original languageEnglish
Article number152255
JournalTetrahedron Letters
Issue number35
Publication statusPublished - 27 Aug 2020

Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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