Different adhesion types and active sensitivity of platelet subpopulations

B. Zhao, T. J. Filler, C. H. Rickert, J. F. Liu, A. D. Skholl-Engberts, V. Gurevich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Two different adhesion patterns of blood platelets with different sensitivity to adenosine were demonstrated by means of reflection contrast microscopy with consecutive image analysis and cell affinity chromatography. High-performance liquid chromatography revealed that thrombin-induced serotonin release of adenosine-sensitive platelets was lower than that of adenosine-resistant cells. Our results indicate platelet heterogeneity and suggest that the platelets with lower adenosine sensitivity may be actively involved in the early interaction between platelets and injured endothelium.

Original languageEnglish
Pages (from-to)322-324
Number of pages3
JournalAmerican Journal of Hematology
Volume52
Issue number4
DOIs
StatePublished - Aug 1996
Externally publishedYes

Scopus subject areas

  • Hematology

Keywords

  • adenosine binding
  • blood platelets
  • heterogeneity
  • platelet adhesion
  • serotonin

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