Developing zebrafish experimental animal models relevant to schizophrenia

Konstantin A. Demin, Darya A. Meshalkina, Andrey D. Volgin, Oleg V. Yakovlev, Murilo S. de Abreu, Polina A. Alekseeva, Ashton J. Friend, Anton M. Lakstygal, Konstantin Zabegalov, Tamara G. Amstislavskaya, Tatyana Strekalova, Wandong Bao, Allan V. Kalueff

Research output

Abstract

Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.

Original languageEnglish
Pages (from-to)126-133
Number of pages8
JournalNeuroscience and Biobehavioral Reviews
Volume105
Early online date29 Jul 2019
DOIs
Publication statusPublished - Oct 2019

Fingerprint

Zebrafish
Schizophrenia
Animal Models
Antipsychotic Agents
Phenotype
Translational Medical Research
Prodrugs
Psychiatry
Pharmaceutical Preparations
Population

Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Demin, Konstantin A. ; Meshalkina, Darya A. ; Volgin, Andrey D. ; Yakovlev, Oleg V. ; de Abreu, Murilo S. ; Alekseeva, Polina A. ; Friend, Ashton J. ; Lakstygal, Anton M. ; Zabegalov, Konstantin ; Amstislavskaya, Tamara G. ; Strekalova, Tatyana ; Bao, Wandong ; Kalueff, Allan V. / Developing zebrafish experimental animal models relevant to schizophrenia. In: Neuroscience and Biobehavioral Reviews. 2019 ; Vol. 105. pp. 126-133.
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abstract = "Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1{\%} of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.",
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Demin, KA, Meshalkina, DA, Volgin, AD, Yakovlev, OV, de Abreu, MS, Alekseeva, PA, Friend, AJ, Lakstygal, AM, Zabegalov, K, Amstislavskaya, TG, Strekalova, T, Bao, W & Kalueff, AV 2019, 'Developing zebrafish experimental animal models relevant to schizophrenia', Neuroscience and Biobehavioral Reviews, vol. 105, pp. 126-133. https://doi.org/10.1016/j.neubiorev.2019.07.017

Developing zebrafish experimental animal models relevant to schizophrenia. / Demin, Konstantin A.; Meshalkina, Darya A.; Volgin, Andrey D.; Yakovlev, Oleg V.; de Abreu, Murilo S.; Alekseeva, Polina A.; Friend, Ashton J.; Lakstygal, Anton M.; Zabegalov, Konstantin; Amstislavskaya, Tamara G.; Strekalova, Tatyana; Bao, Wandong; Kalueff, Allan V.

In: Neuroscience and Biobehavioral Reviews, Vol. 105, 10.2019, p. 126-133.

Research output

TY - JOUR

T1 - Developing zebrafish experimental animal models relevant to schizophrenia

AU - Demin, Konstantin A.

AU - Meshalkina, Darya A.

AU - Volgin, Andrey D.

AU - Yakovlev, Oleg V.

AU - de Abreu, Murilo S.

AU - Alekseeva, Polina A.

AU - Friend, Ashton J.

AU - Lakstygal, Anton M.

AU - Zabegalov, Konstantin

AU - Amstislavskaya, Tamara G.

AU - Strekalova, Tatyana

AU - Bao, Wandong

AU - Kalueff, Allan V.

PY - 2019/10

Y1 - 2019/10

N2 - Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.

AB - Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.

KW - Negative symptoms

KW - Positive symptoms

KW - Rodent models

KW - Schizophrenia

KW - Translational research

KW - Zebrafish

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U2 - 10.1016/j.neubiorev.2019.07.017

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M3 - Review article

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AN - SCOPUS:85070349656

VL - 105

SP - 126

EP - 133

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -