Developing translational biological psychiatry: learning from history to build the future

Константин Андреевич Демин, Дарья Андреевна Мешалкина, Антон Михайлович Лакстыгал, Алан Валерьевич Калуев

Research output

Abstract

Psychiatric disorders are among the most complex human disorders that, albeit
often difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous system
as mental disorders develop. Today’s biological psychiatry is facing multiple
conceptual problems that prevent our deeper understanding of disease
pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.
Original languageEnglish
Pages (from-to)278-292
JournalBiological Communications
Publication statusPublished - 4 May 2018

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Biological Psychiatry
Psychiatry
History
Learning
Mental Disorders

Cite this

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title = "Developing translational biological psychiatry: learning from history to build the future",
abstract = "Psychiatric disorders are among the most complex human disorders that, albeitoften difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous systemas mental disorders develop. Today’s biological psychiatry is facing multipleconceptual problems that prevent our deeper understanding of disease pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.",
author = "Демин, {Константин Андреевич} and Мешалкина, {Дарья Андреевна} and Лакстыгал, {Антон Михайлович} and Калуев, {Алан Валерьевич}",
year = "2018",
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journal = "Biological Communications",
issn = "2542-2154",
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Developing translational biological psychiatry: learning from history to build the future. / Демин, Константин Андреевич; Мешалкина, Дарья Андреевна; Лакстыгал, Антон Михайлович; Калуев, Алан Валерьевич.

In: Biological Communications, 04.05.2018, p. 278-292.

Research output

TY - JOUR

T1 - Developing translational biological psychiatry: learning from history to build the future

AU - Демин, Константин Андреевич

AU - Мешалкина, Дарья Андреевна

AU - Лакстыгал, Антон Михайлович

AU - Калуев, Алан Валерьевич

PY - 2018/5/4

Y1 - 2018/5/4

N2 - Psychiatric disorders are among the most complex human disorders that, albeitoften difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous systemas mental disorders develop. Today’s biological psychiatry is facing multipleconceptual problems that prevent our deeper understanding of disease pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.

AB - Psychiatric disorders are among the most complex human disorders that, albeitoften difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous systemas mental disorders develop. Today’s biological psychiatry is facing multipleconceptual problems that prevent our deeper understanding of disease pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.

M3 - Review article

SP - 278

EP - 292

JO - Biological Communications

JF - Biological Communications

SN - 2542-2154

ER -